Haemophilus influenzae disease in children in India: A hospital perspective

T. Jacob John, Thomas Cherian, P. Raghupathy

Research output: Contribution to journalArticle

Abstract

We review and summarize published information on diseases caused by Haemophilus influenzae in India and unpublished data from our center covering more than three decades. Since the mid-1950s H. influenzae has been the most common cause of pyogenic meningitis in children admitted to our hospital, accounting for one-third to one-half of cases. Information from other centers in India has been scanty; the lower frequency of isolation of Haemophilus in studies in some centers may be caused by unsatisfactory media and culture methods. The annual numbers of admissions for pyogenic meningitis in our hospital have been quite similar to the numbers of cases of poliomyelitis. Assuming that the similar numbers of children hospitalized with these two diseases indicate similar incidence rates in the community and taking into account the frequency of Haemophilus isolations in pyogenic meningitis, we estimate that there may be as many as 75 to 100 cases of meningitis caused by this organism per year per 100 000 children <5 years of age. Although pneumonia caused by H. influenzae has been recognized in a few studies, information is too scanty to attempt the estimation of incidence. Pus- producing infections caused by Haemophilus are rare. Epiglottitis caused by Haemophilus does not seem to occur in India. In recent years we have found that most invasive Haemophilus infections are caused by H. influenzae type b (Hib); other types or untypable strains are infrequent. An increasing prevalence of resistance to chloramphenicol and ampicillin has been recognized in our center and elsewhere. Thus from a hospital perspective, primary prevention by using Hib vaccine seems to be a rational and beneficial intervention. Community-based studies to measure the disease burden of Hib are urgently needed for a more satisfactory assessment of the need for, and cost benefit of, Hib immunization of all infants.

Original languageEnglish (US)
JournalPediatric Infectious Disease Journal
Volume17
Issue number9 SUPPL.
DOIs
StatePublished - Sep 1 1998
Externally publishedYes

Fingerprint

Haemophilus influenzae type b
Haemophilus influenzae
Haemophilus
Meningitis
India
Haemophilus Infections
Haemophilus Vaccines
Epiglottitis
Chloramphenicol Resistance
Ampicillin Resistance
Information Centers
Hospitalized Child
Suppuration
Needs Assessment
Incidence
Poliomyelitis
Primary Prevention
Cost-Benefit Analysis
Culture Media
Immunization

Keywords

  • Haemophilus influenzae
  • Haemophilus influenzae type b
  • India

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)

Cite this

Haemophilus influenzae disease in children in India : A hospital perspective. / John, T. Jacob; Cherian, Thomas; Raghupathy, P.

In: Pediatric Infectious Disease Journal, Vol. 17, No. 9 SUPPL., 01.09.1998.

Research output: Contribution to journalArticle

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