TY - JOUR
T1 - Haemolytic anaemia after childhood Escherichia coli O 157.H7 infection
T2 - Are females at increased risk?
AU - Rowe, P. C.
AU - Walop, W.
AU - Lior, H.
AU - Mackenzie, A. M.
PY - 1991/6
Y1 - 1991/6
N2 - We conducted a 4-year retrospective cohort study to better define the risk of haemolytic anaemia and haemolytic uraemic syndrome (HUS) in children following sporadic gastrointestinal infection with the O 157.H7 serotype of Escherichia coli. Of the 72 children infected with this organism, 9 (12·5%) developed haemolytic anaemia, 6 of whom had HUS. No child in a cohort of 72 age-matched controls with Campylobacter jejuni gastroenteritis developed haemolytic anaemia (P = 0·003). Females had a significantly greater risk of developing haemolytic anaemia after E. coli O 157.H7 infection than did males (8/29 females v. 1/43 males; P = 0·003). In a logistic regression model, female gender emerged as the only statistically significant risk factor for haemolytic anaemia (odds ratio 3·85; 95% confidence interval 1·24–12). These results are consistent with recent reports of a moderate increase in the risk of HUS for females.
AB - We conducted a 4-year retrospective cohort study to better define the risk of haemolytic anaemia and haemolytic uraemic syndrome (HUS) in children following sporadic gastrointestinal infection with the O 157.H7 serotype of Escherichia coli. Of the 72 children infected with this organism, 9 (12·5%) developed haemolytic anaemia, 6 of whom had HUS. No child in a cohort of 72 age-matched controls with Campylobacter jejuni gastroenteritis developed haemolytic anaemia (P = 0·003). Females had a significantly greater risk of developing haemolytic anaemia after E. coli O 157.H7 infection than did males (8/29 females v. 1/43 males; P = 0·003). In a logistic regression model, female gender emerged as the only statistically significant risk factor for haemolytic anaemia (odds ratio 3·85; 95% confidence interval 1·24–12). These results are consistent with recent reports of a moderate increase in the risk of HUS for females.
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U2 - 10.1017/S0950268800067583
DO - 10.1017/S0950268800067583
M3 - Article
C2 - 2050207
AN - SCOPUS:0025911608
SN - 0950-2688
VL - 106
SP - 523
EP - 530
JO - Epidemiology and infection
JF - Epidemiology and infection
IS - 3
ER -