TY - JOUR
T1 - Haemoglobin-e in the presence of oxidative substances from fava bean may be protective against plasmodium falciparum malaria
AU - Kitayapom, Dwip
AU - Nelson, Kenrad E.
AU - Charoenlarp, Pricha
AU - Pholpothi, Tian
N1 - Funding Information:
Acknowledgements This investigation received financial support from the UNDP/World Bank/WHO Special Programmef or Research and Training in Tropical DiseasesW. e thankD r SamartP rasit-chairit, Director, Pong Nam Ron CommunityH ospital, Chan-thaburi, Thailand and his colleaguesf or their efforts and co-operationd uring the entire researchp eriod. We also thank Dr SamuelC haracheo f the HematologyD ivision, Departments of Medicine and Laboratory Medicine of the Johns Hopkins Medical Institution, Baltimore,f or his kind advice,c omments on the manuscript,a nd his particulari nteresti n this research. We alsot hankDr ArwoothN a Lampang,F ield Crop Specialist, Departmento f Agriculture, Bangkok, Dr ThaweesakdBi oon-kerd, Departmento f Botany, Faculty of Science,C hulalong-korn University Bangkok and Mr Kitti Cherdrungsif or their helpfulc onsultationosn the taxonomyo f favab ean.
PY - 1992/6
Y1 - 1992/6
N2 - A case-control study was carried out at a community hospital in eastern Thailand in order to study the association betwen haemoglobin E and Plasmodium falciparum malaria; 271 P. falciparum cases and 271 controls were enrolled. After adjusting for age, sex, time since last malaria attack, history of mosquito net use, and history of fava bean consumption in the previous month, neither heterozygous nor homozygous haemoglobin E provided significant protection against P. falciparum infection, with odds ratios (OR)=0•91 (95% confidence limits=0•61, 1•36) and 0•78 (0•34, 1•82) respectively when compared to persons with haemoglobin A who were not consumers of fava beans. However, haemoglobin E carriers who ate fava beans were significantly protected against P. falciparum malaria with C)R=0•26 (0•09, 0•76) and C)R=0•001 (0•00, 1120•59) for subjects with heterozygous and homozygous haemoglobin E, respectively. The study suggests a possible synergistic protective effect of haemoglobin E on the risk of P. falciparum malaria in subjects who have consumed fava beans.
AB - A case-control study was carried out at a community hospital in eastern Thailand in order to study the association betwen haemoglobin E and Plasmodium falciparum malaria; 271 P. falciparum cases and 271 controls were enrolled. After adjusting for age, sex, time since last malaria attack, history of mosquito net use, and history of fava bean consumption in the previous month, neither heterozygous nor homozygous haemoglobin E provided significant protection against P. falciparum infection, with odds ratios (OR)=0•91 (95% confidence limits=0•61, 1•36) and 0•78 (0•34, 1•82) respectively when compared to persons with haemoglobin A who were not consumers of fava beans. However, haemoglobin E carriers who ate fava beans were significantly protected against P. falciparum malaria with C)R=0•26 (0•09, 0•76) and C)R=0•001 (0•00, 1120•59) for subjects with heterozygous and homozygous haemoglobin E, respectively. The study suggests a possible synergistic protective effect of haemoglobin E on the risk of P. falciparum malaria in subjects who have consumed fava beans.
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U2 - 10.1016/0035-9203(92)90292-K
DO - 10.1016/0035-9203(92)90292-K
M3 - Article
C2 - 1412643
AN - SCOPUS:0026632395
SN - 0035-9203
VL - 86
SP - 240
EP - 244
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
IS - 3
ER -