A case-control study was carried out at a community hospital in eastern Thailand in order to study the association betwen haemoglobin E and Plasmodium falciparum malaria; 271 P. falciparum cases and 271 controls were enrolled. After adjusting for age, sex, time since last malaria attack, history of mosquito net use, and history of fava bean consumption in the previous month, neither heterozygous nor homozygous haemoglobin E provided significant protection against P. falciparum infection, with odds ratios (OR)=0•91 (95% confidence limits=0•61, 1•36) and 0•78 (0•34, 1•82) respectively when compared to persons with haemoglobin A who were not consumers of fava beans. However, haemoglobin E carriers who ate fava beans were significantly protected against P. falciparum malaria with C)R=0•26 (0•09, 0•76) and C)R=0•001 (0•00, 1120•59) for subjects with heterozygous and homozygous haemoglobin E, respectively. The study suggests a possible synergistic protective effect of haemoglobin E on the risk of P. falciparum malaria in subjects who have consumed fava beans.
|Original language||English (US)|
|Number of pages||5|
|Journal||Transactions of the Royal Society of Tropical Medicine and Hygiene|
|State||Published - Jun 1992|
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Infectious Diseases