Systemic diseases often first become obvious through impairment of blood cell production. There is no correlation between the severity of the blood abnormality and the nature of the underlying cause. Anaemia is the most common abnormality associated with systemic disease. Recognition of the anaemia of chronic disorders is important since correction of the anaemia is dependent upon correction of the underlying systemic disease. Small molecules, such as hepcidin, appear to play a key role in the development of the anaemia of chronic disease through interference with iron absorption from the gut, as well as impairing iron release from macrophages.
|Original language||English (US)|
|Number of pages||4|
|Journal||Clinical Medicine, Journal of the Royal College of Physicians of London|
|State||Published - 2005|
- Anaemia of chronic disease
ASJC Scopus subject areas