Haematological manifestations of systemic disease

Research output: Contribution to journalReview articlepeer-review


Systemic diseases often first become obvious through impairment of blood cell production. There is no correlation between the severity of the blood abnormality and the nature of the underlying cause. Anaemia is the most common abnormality associated with systemic disease. Recognition of the anaemia of chronic disorders is important since correction of the anaemia is dependent upon correction of the underlying systemic disease. Small molecules, such as hepcidin, appear to play a key role in the development of the anaemia of chronic disease through interference with iron absorption from the gut, as well as impairing iron release from macrophages.

Original languageEnglish (US)
Pages (from-to)322-325
Number of pages4
JournalClinical Medicine, Journal of the Royal College of Physicians of London
Issue number4
StatePublished - 2005


  • Anaemia
  • Anaemia of chronic disease
  • Coagulation
  • Leukocytes
  • Platelets

ASJC Scopus subject areas

  • Medicine(all)


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