Haematological indices as predictors of atrial fibrillation following isolated coronary artery bypass grafting, valvular surgery, or combined procedures

A systematic review with meta-analysis

Alexander Weymann, Sadeq Ali-Hasan-Al-Saegh, Aron Frederik Popov, Anton Sabashnikov, Seyed Jalil Mirhosseini, Tong Liu, Gary Tse, Mohammadreza Lotfaliani, Azam Ghanei, Luca Testa, Fabrizio D’Ascenzo, Umberto Benedetto, Hamidreza Dehghan, Leonardo Roever, Michel Pompeu Barros De Oliveira Sá, William L. Baker, Senol Yavuz, Mohamed Zeriouh, Ahmed Mashhour, Luis Nombela-Franco & 10 others Jae Sik Jang, Lei Meng, Mengqi Gong, Abhishek J. Deshmukh, Tullio Palmerini, Cecilia Linde, Krzysztof J. Filipiak, Giuseppe Biondi-Zoccai, Hugh Calkins, Gregg W. Stone

Research output: Contribution to journalArticle

Abstract

Background: New postoperative atrial fibrillation (POAF) is one of the most critical and common complications after cardiovascular surgery precipitating early and late morbidities. Complete blood count (CBC) is an imperative blood test in clinical practice, routinely used in the examination of cardiovascular diseases. Aim: This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of haematological indices in CBC tests with atrial fibrillation following isolated coronary artery bypass graft (CABG), isolated valvular surgery, or a combination of these treatments. Methods: We conducted a meta-analysis of studies evaluating pre- and postoperative haematological indices in patients with POAF. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity. Results: A literature search of all major databases retrieved 732 studies. After screening, 22 studies were analysed including a total of 6098 patients. Pooled analysis showed preoperative platelet count (PC) (weighted mean difference [WMD] = –7.07 × 109/L and p < 0.001), preoperative mean platelet volume (MPV) (WMD = 0.53 FL and p < 0.001), preoperative white blood cell count (WBC) (WMD = 0.130 × 109/L and p < 0.001), preoperative neutrophil-to-lymphocyte ratio (NLR) (WMD = 0.33 and p < 0.001), preoperative red blood cell distribution width (RDW) (WMD = 0.36% and p < 0.001), postoperative WBC (WMD = 1.36 × 109/L and p < 0.001), and postoperative NLR (WMD = 0.74 and p < 0.001) as associated factors with POAF. Conclusions: Haematological indices may predict the risk of POAF before surgery. These easily-performed tests should definitely be taken into account in patients undergoing isolated CABG, valvular surgery, or combined procedures.

Original languageEnglish (US)
Pages (from-to)107-118
Number of pages12
JournalKardiologia Polska
Volume76
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Coronary Artery Bypass
Atrial Fibrillation
Meta-Analysis
Blood Cell Count
Hematologic Tests
Leukocyte Count
Neutrophils
Mean Platelet Volume
Lymphocytes
Transplants
Erythrocyte Indices
Platelet Count
Cardiovascular Diseases
Erythrocytes
Databases
Morbidity
Therapeutics

Keywords

  • Atrial fibrillation
  • Cardiac surgical procedure
  • Complete blood count
  • Coronary artery bypass
  • Meta-analysis
  • Review

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Haematological indices as predictors of atrial fibrillation following isolated coronary artery bypass grafting, valvular surgery, or combined procedures : A systematic review with meta-analysis. / Weymann, Alexander; Ali-Hasan-Al-Saegh, Sadeq; Popov, Aron Frederik; Sabashnikov, Anton; Mirhosseini, Seyed Jalil; Liu, Tong; Tse, Gary; Lotfaliani, Mohammadreza; Ghanei, Azam; Testa, Luca; D’Ascenzo, Fabrizio; Benedetto, Umberto; Dehghan, Hamidreza; Roever, Leonardo; De Oliveira Sá, Michel Pompeu Barros; Baker, William L.; Yavuz, Senol; Zeriouh, Mohamed; Mashhour, Ahmed; Nombela-Franco, Luis; Jang, Jae Sik; Meng, Lei; Gong, Mengqi; Deshmukh, Abhishek J.; Palmerini, Tullio; Linde, Cecilia; Filipiak, Krzysztof J.; Biondi-Zoccai, Giuseppe; Calkins, Hugh; Stone, Gregg W.

In: Kardiologia Polska, Vol. 76, No. 1, 01.01.2018, p. 107-118.

Research output: Contribution to journalArticle

Weymann, A, Ali-Hasan-Al-Saegh, S, Popov, AF, Sabashnikov, A, Mirhosseini, SJ, Liu, T, Tse, G, Lotfaliani, M, Ghanei, A, Testa, L, D’Ascenzo, F, Benedetto, U, Dehghan, H, Roever, L, De Oliveira Sá, MPB, Baker, WL, Yavuz, S, Zeriouh, M, Mashhour, A, Nombela-Franco, L, Jang, JS, Meng, L, Gong, M, Deshmukh, AJ, Palmerini, T, Linde, C, Filipiak, KJ, Biondi-Zoccai, G, Calkins, H & Stone, GW 2018, 'Haematological indices as predictors of atrial fibrillation following isolated coronary artery bypass grafting, valvular surgery, or combined procedures: A systematic review with meta-analysis', Kardiologia Polska, vol. 76, no. 1, pp. 107-118. https://doi.org/10.5603/KP.a2017.0179
Weymann, Alexander ; Ali-Hasan-Al-Saegh, Sadeq ; Popov, Aron Frederik ; Sabashnikov, Anton ; Mirhosseini, Seyed Jalil ; Liu, Tong ; Tse, Gary ; Lotfaliani, Mohammadreza ; Ghanei, Azam ; Testa, Luca ; D’Ascenzo, Fabrizio ; Benedetto, Umberto ; Dehghan, Hamidreza ; Roever, Leonardo ; De Oliveira Sá, Michel Pompeu Barros ; Baker, William L. ; Yavuz, Senol ; Zeriouh, Mohamed ; Mashhour, Ahmed ; Nombela-Franco, Luis ; Jang, Jae Sik ; Meng, Lei ; Gong, Mengqi ; Deshmukh, Abhishek J. ; Palmerini, Tullio ; Linde, Cecilia ; Filipiak, Krzysztof J. ; Biondi-Zoccai, Giuseppe ; Calkins, Hugh ; Stone, Gregg W. / Haematological indices as predictors of atrial fibrillation following isolated coronary artery bypass grafting, valvular surgery, or combined procedures : A systematic review with meta-analysis. In: Kardiologia Polska. 2018 ; Vol. 76, No. 1. pp. 107-118.
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abstract = "Background: New postoperative atrial fibrillation (POAF) is one of the most critical and common complications after cardiovascular surgery precipitating early and late morbidities. Complete blood count (CBC) is an imperative blood test in clinical practice, routinely used in the examination of cardiovascular diseases. Aim: This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of haematological indices in CBC tests with atrial fibrillation following isolated coronary artery bypass graft (CABG), isolated valvular surgery, or a combination of these treatments. Methods: We conducted a meta-analysis of studies evaluating pre- and postoperative haematological indices in patients with POAF. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity. Results: A literature search of all major databases retrieved 732 studies. After screening, 22 studies were analysed including a total of 6098 patients. Pooled analysis showed preoperative platelet count (PC) (weighted mean difference [WMD] = –7.07 × 109/L and p < 0.001), preoperative mean platelet volume (MPV) (WMD = 0.53 FL and p < 0.001), preoperative white blood cell count (WBC) (WMD = 0.130 × 109/L and p < 0.001), preoperative neutrophil-to-lymphocyte ratio (NLR) (WMD = 0.33 and p < 0.001), preoperative red blood cell distribution width (RDW) (WMD = 0.36{\%} and p < 0.001), postoperative WBC (WMD = 1.36 × 109/L and p < 0.001), and postoperative NLR (WMD = 0.74 and p < 0.001) as associated factors with POAF. Conclusions: Haematological indices may predict the risk of POAF before surgery. These easily-performed tests should definitely be taken into account in patients undergoing isolated CABG, valvular surgery, or combined procedures.",
keywords = "Atrial fibrillation, Cardiac surgical procedure, Complete blood count, Coronary artery bypass, Meta-analysis, Review",
author = "Alexander Weymann and Sadeq Ali-Hasan-Al-Saegh and Popov, {Aron Frederik} and Anton Sabashnikov and Mirhosseini, {Seyed Jalil} and Tong Liu and Gary Tse and Mohammadreza Lotfaliani and Azam Ghanei and Luca Testa and Fabrizio D’Ascenzo and Umberto Benedetto and Hamidreza Dehghan and Leonardo Roever and {De Oliveira S{\'a}}, {Michel Pompeu Barros} and Baker, {William L.} and Senol Yavuz and Mohamed Zeriouh and Ahmed Mashhour and Luis Nombela-Franco and Jang, {Jae Sik} and Lei Meng and Mengqi Gong and Deshmukh, {Abhishek J.} and Tullio Palmerini and Cecilia Linde and Filipiak, {Krzysztof J.} and Giuseppe Biondi-Zoccai and Hugh Calkins and Stone, {Gregg W.}",
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T1 - Haematological indices as predictors of atrial fibrillation following isolated coronary artery bypass grafting, valvular surgery, or combined procedures

T2 - A systematic review with meta-analysis

AU - Weymann, Alexander

AU - Ali-Hasan-Al-Saegh, Sadeq

AU - Popov, Aron Frederik

AU - Sabashnikov, Anton

AU - Mirhosseini, Seyed Jalil

AU - Liu, Tong

AU - Tse, Gary

AU - Lotfaliani, Mohammadreza

AU - Ghanei, Azam

AU - Testa, Luca

AU - D’Ascenzo, Fabrizio

AU - Benedetto, Umberto

AU - Dehghan, Hamidreza

AU - Roever, Leonardo

AU - De Oliveira Sá, Michel Pompeu Barros

AU - Baker, William L.

AU - Yavuz, Senol

AU - Zeriouh, Mohamed

AU - Mashhour, Ahmed

AU - Nombela-Franco, Luis

AU - Jang, Jae Sik

AU - Meng, Lei

AU - Gong, Mengqi

AU - Deshmukh, Abhishek J.

AU - Palmerini, Tullio

AU - Linde, Cecilia

AU - Filipiak, Krzysztof J.

AU - Biondi-Zoccai, Giuseppe

AU - Calkins, Hugh

AU - Stone, Gregg W.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: New postoperative atrial fibrillation (POAF) is one of the most critical and common complications after cardiovascular surgery precipitating early and late morbidities. Complete blood count (CBC) is an imperative blood test in clinical practice, routinely used in the examination of cardiovascular diseases. Aim: This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of haematological indices in CBC tests with atrial fibrillation following isolated coronary artery bypass graft (CABG), isolated valvular surgery, or a combination of these treatments. Methods: We conducted a meta-analysis of studies evaluating pre- and postoperative haematological indices in patients with POAF. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity. Results: A literature search of all major databases retrieved 732 studies. After screening, 22 studies were analysed including a total of 6098 patients. Pooled analysis showed preoperative platelet count (PC) (weighted mean difference [WMD] = –7.07 × 109/L and p < 0.001), preoperative mean platelet volume (MPV) (WMD = 0.53 FL and p < 0.001), preoperative white blood cell count (WBC) (WMD = 0.130 × 109/L and p < 0.001), preoperative neutrophil-to-lymphocyte ratio (NLR) (WMD = 0.33 and p < 0.001), preoperative red blood cell distribution width (RDW) (WMD = 0.36% and p < 0.001), postoperative WBC (WMD = 1.36 × 109/L and p < 0.001), and postoperative NLR (WMD = 0.74 and p < 0.001) as associated factors with POAF. Conclusions: Haematological indices may predict the risk of POAF before surgery. These easily-performed tests should definitely be taken into account in patients undergoing isolated CABG, valvular surgery, or combined procedures.

AB - Background: New postoperative atrial fibrillation (POAF) is one of the most critical and common complications after cardiovascular surgery precipitating early and late morbidities. Complete blood count (CBC) is an imperative blood test in clinical practice, routinely used in the examination of cardiovascular diseases. Aim: This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of haematological indices in CBC tests with atrial fibrillation following isolated coronary artery bypass graft (CABG), isolated valvular surgery, or a combination of these treatments. Methods: We conducted a meta-analysis of studies evaluating pre- and postoperative haematological indices in patients with POAF. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity. Results: A literature search of all major databases retrieved 732 studies. After screening, 22 studies were analysed including a total of 6098 patients. Pooled analysis showed preoperative platelet count (PC) (weighted mean difference [WMD] = –7.07 × 109/L and p < 0.001), preoperative mean platelet volume (MPV) (WMD = 0.53 FL and p < 0.001), preoperative white blood cell count (WBC) (WMD = 0.130 × 109/L and p < 0.001), preoperative neutrophil-to-lymphocyte ratio (NLR) (WMD = 0.33 and p < 0.001), preoperative red blood cell distribution width (RDW) (WMD = 0.36% and p < 0.001), postoperative WBC (WMD = 1.36 × 109/L and p < 0.001), and postoperative NLR (WMD = 0.74 and p < 0.001) as associated factors with POAF. Conclusions: Haematological indices may predict the risk of POAF before surgery. These easily-performed tests should definitely be taken into account in patients undergoing isolated CABG, valvular surgery, or combined procedures.

KW - Atrial fibrillation

KW - Cardiac surgical procedure

KW - Complete blood count

KW - Coronary artery bypass

KW - Meta-analysis

KW - Review

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