Haematological indices as predictors of atrial fibrillation following isolated coronary artery bypass grafting, valvular surgery, or combined procedures: A systematic review with meta-analysis

Alexander Weymann, Sadeq Ali-Hasan-Al-Saegh, Aron Frederik Popov, Anton Sabashnikov, Seyed Jalil Mirhosseini, Tong Liu, Gary Tse, Mohammadreza Lotfaliani, Azam Ghanei, Luca Testa, Fabrizio D’Ascenzo, Umberto Benedetto, Hamidreza Dehghan, Leonardo Roever, Michel Pompeu Barros De Oliveira Sá, William L. Baker, Senol Yavuz, Mohamed Zeriouh, Ahmed Mashhour, Luis Nombela-FrancoJae Sik Jang, Lei Meng, Mengqi Gong, Abhishek J. Deshmukh, Tullio Palmerini, Cecilia Linde, Krzysztof J. Filipiak, Giuseppe Biondi-Zoccai, Hugh Calkins, Gregg W. Stone

Research output: Contribution to journalArticle

Abstract

Background: New postoperative atrial fibrillation (POAF) is one of the most critical and common complications after cardiovascular surgery precipitating early and late morbidities. Complete blood count (CBC) is an imperative blood test in clinical practice, routinely used in the examination of cardiovascular diseases. Aim: This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of haematological indices in CBC tests with atrial fibrillation following isolated coronary artery bypass graft (CABG), isolated valvular surgery, or a combination of these treatments. Methods: We conducted a meta-analysis of studies evaluating pre- and postoperative haematological indices in patients with POAF. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity. Results: A literature search of all major databases retrieved 732 studies. After screening, 22 studies were analysed including a total of 6098 patients. Pooled analysis showed preoperative platelet count (PC) (weighted mean difference [WMD] = –7.07 × 109/L and p < 0.001), preoperative mean platelet volume (MPV) (WMD = 0.53 FL and p < 0.001), preoperative white blood cell count (WBC) (WMD = 0.130 × 109/L and p < 0.001), preoperative neutrophil-to-lymphocyte ratio (NLR) (WMD = 0.33 and p < 0.001), preoperative red blood cell distribution width (RDW) (WMD = 0.36% and p < 0.001), postoperative WBC (WMD = 1.36 × 109/L and p < 0.001), and postoperative NLR (WMD = 0.74 and p < 0.001) as associated factors with POAF. Conclusions: Haematological indices may predict the risk of POAF before surgery. These easily-performed tests should definitely be taken into account in patients undergoing isolated CABG, valvular surgery, or combined procedures.

Original languageEnglish (US)
Pages (from-to)107-118
Number of pages12
JournalKardiologia Polska
Volume76
Issue number1
DOIs
StatePublished - Jan 1 2018

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Keywords

  • Atrial fibrillation
  • Cardiac surgical procedure
  • Complete blood count
  • Coronary artery bypass
  • Meta-analysis
  • Review

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Weymann, A., Ali-Hasan-Al-Saegh, S., Popov, A. F., Sabashnikov, A., Mirhosseini, S. J., Liu, T., Tse, G., Lotfaliani, M., Ghanei, A., Testa, L., D’Ascenzo, F., Benedetto, U., Dehghan, H., Roever, L., De Oliveira Sá, M. P. B., Baker, W. L., Yavuz, S., Zeriouh, M., Mashhour, A., ... Stone, G. W. (2018). Haematological indices as predictors of atrial fibrillation following isolated coronary artery bypass grafting, valvular surgery, or combined procedures: A systematic review with meta-analysis. Kardiologia Polska, 76(1), 107-118. https://doi.org/10.5603/KP.a2017.0179