@article{375e97639b6840adacdc7f6b25800421,
title = "Haem oxygenase-1 prevents cell death by regulating cellular iron",
abstract = "Haem oxygenase-1 (HO1) is a heat-shock protein that is induced by stressful stimuli. Here we demonstrate a cytoprotective role for HO1: cell death produced by serum deprivation, staurosporine or etoposide is markedly accentuated in cells from mice with a targeted deletion of the HO1 gene, and greatly reduced in cells that overexpress HO1. Iron efflux from cells is augmented by HO1 transfection and reduced in HO1-deficient fibroblasts. Iron accumulation in HO1-deficient cells explains their death: iron chelators protect HO1-deficient fibroblasts from cell death. Thus, cytoprotection by HO1 is attributable to its augmentation of iron efflux, reflecting a role for HO1 in modulating intracellular iron levels and regulating cell viability.",
author = "Ferris, {Christopher D.} and Jaffrey, {Samie R.} and Akira Sawa and Masaaki Takahashi and Brady, {Stephen D.} and Barrow, {Roxanne K.} and Tysoe, {Steven A.} and Herman Wolosker and Bara{\~n}ano, {David E.} and Sylvain Dor{\'e} and Poss, {Kenneth D.} and Snyder, {Solomon H.}",
note = "Funding Information: ACKNOWLEDGEMENTS We thank R. Seaforth for providing [55Fe]haemin, D. C. Dodson for secretarial assistance, and S. Tonegawa for initial supplies of HO1−/− mice. This work was supported by USPHS grant MH-18501 and Research Scientist Award DA-00074 to S.H.S., and a National Research Service Award (DA-05900) to D.E.B. C.D.F. has a Howard Hughes Fellowship for Physicians and H.W. is a Pew Fellow. Correspondence and requests for materials should be addressed to S.H.S. or C.D.F. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "1999",
month = jul,
doi = "10.1038/11072",
language = "English (US)",
volume = "1",
pages = "152--157",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "Nature Publishing Group",
number = "3",
}