Abstract
DATA from lesion studies data indicate that the removal of the medial cerebellum prevents acquisition but not reten-tion of long-term habituation (LTH) of the acoustic startle response (ASR). The spreading depression (SD) of the vermis was used to examine under more functional conditions the build-up of LTH of the ASR in Wistar rats. Our findings showed that reversible blockade of the vermis during training disrupted LTH of the ASR without changing within-trials habituation. In contrast to previous data, the present results suggest that SD strongly affects the amplitude of the startle response. The data are discussed in respect to a role of the vermis in the control of emotional behaviour in animals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2065-2068 |
| Number of pages | 4 |
| Journal | NeuroReport |
| Volume | 5 |
| Issue number | 16 |
| State | Published - 1994 |
| Externally published | Yes |
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Keywords
- Habituation
- Rats
- Spreading depression
- Startle
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Habituation of acoustic startle in rats—a functional ablation study. / Storozeva, Zinaida I.; Pletnikov, Mikhail.
In: NeuroReport, Vol. 5, No. 16, 1994, p. 2065-2068.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Habituation of acoustic startle in rats—a functional ablation study
AU - Storozeva, Zinaida I.
AU - Pletnikov, Mikhail
PY - 1994
Y1 - 1994
N2 - DATA from lesion studies data indicate that the removal of the medial cerebellum prevents acquisition but not reten-tion of long-term habituation (LTH) of the acoustic startle response (ASR). The spreading depression (SD) of the vermis was used to examine under more functional conditions the build-up of LTH of the ASR in Wistar rats. Our findings showed that reversible blockade of the vermis during training disrupted LTH of the ASR without changing within-trials habituation. In contrast to previous data, the present results suggest that SD strongly affects the amplitude of the startle response. The data are discussed in respect to a role of the vermis in the control of emotional behaviour in animals.
AB - DATA from lesion studies data indicate that the removal of the medial cerebellum prevents acquisition but not reten-tion of long-term habituation (LTH) of the acoustic startle response (ASR). The spreading depression (SD) of the vermis was used to examine under more functional conditions the build-up of LTH of the ASR in Wistar rats. Our findings showed that reversible blockade of the vermis during training disrupted LTH of the ASR without changing within-trials habituation. In contrast to previous data, the present results suggest that SD strongly affects the amplitude of the startle response. The data are discussed in respect to a role of the vermis in the control of emotional behaviour in animals.
KW - Habituation
KW - Rats
KW - Spreading depression
KW - Startle
UR - http://www.scopus.com/inward/record.url?scp=0028046855&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028046855&partnerID=8YFLogxK
M3 - Article
C2 - 7865746
AN - SCOPUS:0028046855
VL - 5
SP - 2065
EP - 2068
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 16
ER -