Habituation of acoustic startle in rats—a functional ablation study

Zinaida I. Storozeva, Michail V. Pletnicov

Research output: Contribution to journalArticlepeer-review

Abstract

DATA from lesion studies data indicate that the removal of the medial cerebellum prevents acquisition but not reten-tion of long-term habituation (LTH) of the acoustic startle response (ASR). The spreading depression (SD) of the vermis was used to examine under more functional conditions the build-up of LTH of the ASR in Wistar rats. Our findings showed that reversible blockade of the vermis during training disrupted LTH of the ASR without changing within-trials habituation. In contrast to previous data, the present results suggest that SD strongly affects the amplitude of the startle response. The data are discussed in respect to a role of the vermis in the control of emotional behaviour in animals.

Original languageEnglish (US)
Pages (from-to)2065-2068
Number of pages4
JournalNeuroreport
Volume5
Issue number16
DOIs
StatePublished - Oct 1994
Externally publishedYes

Keywords

  • Habituation
  • Rats
  • Spreading depression
  • Startle

ASJC Scopus subject areas

  • Neuroscience(all)

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