HA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces N-methyl-d-aspartate (NMDA)-mediated brain damage

John W. McDonald, John Uckele, Faye S. Silverstein, Michael V. Johnston

Research output: Contribution to journalArticlepeer-review

Abstract

The neuroprotective effects of the strychnine-insensitive glycine receptor antagonist, HA-966, against N-methyl-d-aspartate (NMDA)- and quisqualate (QA)-mediated brain injury were determined in perinatal rats. Postnatal day (PND) 7 rats received intrastriatal injections of NMDA (25 nmol) or QA (100 nmol) and then were administered intraperitoneal (i.p.) injections of varying doses of HA-966 or vehicle 15 min later. Animals were sacrificed 5 days later and the degree of brain injury was calculated by comparison of the weights of injected and contralateral cerebral hemispheres. HA-966 selectively reduced the degree of NMDA-mediated brain injury in a dose-dependent manner. However, HA-966 did not attenuate QA-mediated brain injury.

Original languageEnglish (US)
Pages (from-to)167-170
Number of pages4
JournalNeuroscience Letters
Volume104
Issue number1-2
DOIs
StatePublished - Sep 25 1989

Keywords

  • MK-801
  • N-Methyl-d-aspartate
  • Neuroprotection
  • Neurotoxicity
  • Phencyclidine
  • Rat brain
  • Strychnine-insensitive glycine receptor

ASJC Scopus subject areas

  • Neuroscience(all)

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