Gynaecological and obstetrical morbidity in women with type I von Willebrand disease: Results of a patient survey

P. A. Kouides, P. D. Phatak, P. Burkart, C. Braggins, Christopher Cox, Z. Bernstein, L. Belling, P. Holmberg, W. Maclaughlin, F. Howard

Research output: Contribution to journalArticle

Abstract

Type 1 von Willebrand disease (vWD) is generally regarded clinically as 'mild' and the obstetrical-gynaecological features have not been fully described. We administered a patient questionnaire and provider survey of the medical and quality of life aspects of childbirth and menstruation to 99 type 1 vWD patients and compared the patients presently menstruating (n = 81) to a cohort of 150 menstruating females in the general population. The following measurements had a statistically higher proportion in the vWD group: number of tampons/towels used for a typical menstrual cycle (P = 0.002); percentage reporting that clothes are stained by menses (P = 0.001); past or present history of anaemia (P = 0.001); childbirth-related bleeding (P = 0.001); and childbirth-related bleeding necessitating RBC transfusion (P = 0.002). Quality of life assessment of the impact of menses in both of the above cohorts was measured by a Likert scale using seven quality of life parameters. Compared to the control group, the vWD patients had a significantly higher score, with P-values of <0.0001 for each parameter. Hormonal interventions for menorrhagia in the vWD patients were ≤ 50% effective. Menorrhagia resulted in red blood cell transfusions in 6% of patients, dilatation and curettage in 17% and hysterectomy in 13%. Despite the common connotation of type 1 vWD as clinically 'mild', childbirth and the monthly challenge to haemostasis presented by menstruation result in a substantial degree of morbidity in females with type 1 vWD. These results support the rationale for ongoing international efforts to increase awareness of vWD as a cause for menorrhagia and to improve the quality of life in females with known vWD.

Original languageEnglish (US)
Pages (from-to)643-648
Number of pages6
JournalHaemophilia
Volume6
Issue number6
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Type 1 von Willebrand Disease
von Willebrand Diseases
Menstruation
Morbidity
Menorrhagia
Quality of Life
Parturition
Hemorrhage
Dilatation and Curettage
Erythrocyte Transfusion
Clothing
Menstrual Cycle
Hemostasis
Hysterectomy
Surveys and Questionnaires
Anemia
Control Groups

Keywords

  • Gynaecology
  • Menorrhagia
  • Obstetrics
  • Postpartum haemorrhage
  • Quality of life
  • Von willebrand disease

ASJC Scopus subject areas

  • Hematology

Cite this

Gynaecological and obstetrical morbidity in women with type I von Willebrand disease : Results of a patient survey. / Kouides, P. A.; Phatak, P. D.; Burkart, P.; Braggins, C.; Cox, Christopher; Bernstein, Z.; Belling, L.; Holmberg, P.; Maclaughlin, W.; Howard, F.

In: Haemophilia, Vol. 6, No. 6, 2000, p. 643-648.

Research output: Contribution to journalArticle

Kouides, PA, Phatak, PD, Burkart, P, Braggins, C, Cox, C, Bernstein, Z, Belling, L, Holmberg, P, Maclaughlin, W & Howard, F 2000, 'Gynaecological and obstetrical morbidity in women with type I von Willebrand disease: Results of a patient survey', Haemophilia, vol. 6, no. 6, pp. 643-648. https://doi.org/10.1046/j.1365-2516.2000.00447.x
Kouides, P. A. ; Phatak, P. D. ; Burkart, P. ; Braggins, C. ; Cox, Christopher ; Bernstein, Z. ; Belling, L. ; Holmberg, P. ; Maclaughlin, W. ; Howard, F. / Gynaecological and obstetrical morbidity in women with type I von Willebrand disease : Results of a patient survey. In: Haemophilia. 2000 ; Vol. 6, No. 6. pp. 643-648.
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AU - Braggins, C.

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