GWAS signals across the HLA regions: revealing a clue for common etiology underlying infectious tumors and other immunity diseases.

Yin Yao Shugart, Ying Wang, Wei Hua Jia, Yi Xin Zeng

Research output: Contribution to journalArticlepeer-review

Abstract

Increasing evidence suggests that multiple genes in the human leukocyte antigen(HLA) regions play an important role in development of cancers and immunity disorders. However, the biological mechanisms of the HLA associations are not well understood. We recently conducted a survey of all genome-wide association studies (GWAS) with significant findings in the HLA regions and concluded that diseases such as cancer and immune disorders are more likely to be associated with genetic variants located in the HLA regions than other diseases. This finding is suggestive for testing a hypothesis of a common etiology of infectious tumors and other immunity diseases.

Original languageEnglish (US)
Pages (from-to)226-230
Number of pages5
JournalChinese Journal of Cancer
Volume30
Issue number4
StatePublished - Apr 2011
Externally publishedYes

ASJC Scopus subject areas

  • Oncology

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