Gut peptides in the control of food intake: 30 Years of ideas

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55 Scopus citations


The demonstration of the ability of exogenous cholecystokinin (CCK) to inhibit food intake began a series of investigations into whether and how gut and brain peptides affected ingestive behavior. In that original demonstration, Gerry Smith and colleagues both established criteria for evaluating roles for gut peptides in food intake and shifted the focus of feeding controls to factors that contribute to limiting meal size. Although new gut peptides with novel mechanisms and durations of action have been identified in the past few years, Smith's criteria and his distinction between direct and indirect controls of meal size continue to provide a framework for understanding how such peptides may contribute to overall feeding control.

Original languageEnglish (US)
Pages (from-to)175-180
Number of pages6
JournalPhysiology and Behavior
Issue number1
StatePublished - Aug 2004


  • Cholecystokinin
  • Food intake
  • Gut peptides

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience


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