TY - JOUR
T1 - Gut microbiota in renal physiology
T2 - focus on short-chain fatty acids and their receptors
AU - Pluznick, Jennifer L.
N1 - Funding Information:
The author would like to thank Niranjana Natarajan for helpful discussions related to this article. This work was supported by National Institutes of Health grant R01DK107726, National Institutes of Health grant R01HL128512, American Heart Association 16IRG27260265, and Hopkins Conte Digestive Diseases Basic and Translational Research Core Center.
Publisher Copyright:
© 2016 International Society of Nephrology
PY - 2016/12/1
Y1 - 2016/12/1
N2 - A number of recent studies have begun to explore a new and exciting area: the interaction between the gut microbiome and renal physiology. In particular, multiple studies have focused on the role of microbially produced short chain fatty acids, which are generally thought to promote health. This review will focus on what is known to date regarding the influence of the microbiome on renal function, with emphasis on the cell biology, physiology, and clinical implications of short chain fatty acids and short chain fatty acid receptors. It is clear that microbe-host interactions are an exciting and ever-expanding field, which has implications for how we view diseases such as hypertension, acute kidney injury, and chronic kidney disease. However, it is important to recognize that although the potential promise of this area is extremely enticing, we are only the very edge of this new field.
AB - A number of recent studies have begun to explore a new and exciting area: the interaction between the gut microbiome and renal physiology. In particular, multiple studies have focused on the role of microbially produced short chain fatty acids, which are generally thought to promote health. This review will focus on what is known to date regarding the influence of the microbiome on renal function, with emphasis on the cell biology, physiology, and clinical implications of short chain fatty acids and short chain fatty acid receptors. It is clear that microbe-host interactions are an exciting and ever-expanding field, which has implications for how we view diseases such as hypertension, acute kidney injury, and chronic kidney disease. However, it is important to recognize that although the potential promise of this area is extremely enticing, we are only the very edge of this new field.
KW - acute kidney injury
KW - antibiotics
KW - cell signaling
KW - chronic kidney disease
UR - http://www.scopus.com/inward/record.url?scp=84994071247&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84994071247&partnerID=8YFLogxK
U2 - 10.1016/j.kint.2016.06.033
DO - 10.1016/j.kint.2016.06.033
M3 - Review article
C2 - 27575555
AN - SCOPUS:84994071247
SN - 0085-2538
VL - 90
SP - 1191
EP - 1198
JO - Kidney international
JF - Kidney international
IS - 6
ER -