Gut Microbiome and AKI: Roles of the Immune System and Short-Chain Fatty Acids

Sepideh Gharaie, Sanjeev Noel, Hamid Rabb

Research output: Contribution to journalReview articlepeer-review

Abstract

Acute kidney injury (AKI) is a common and serious syndrome that involves multiple pathophysiologic mechanisms. Recent studies have demonstrated that dysbiosis of the gut microbiota mediates experimental AKI. The precise microbial populations involved and the underlying mechanisms are currently being explored. In this mini-review based on the NIH AKI O'Brien Center symposium of February 2020, we discuss data on gut microbiota in AKI with a focus on the immune system and short-chain fatty acids as mediators of microbiome-kidney crosstalk.

Original languageEnglish (US)
Pages (from-to)662-664
Number of pages3
JournalNephron
Volume144
Issue number12
DOIs
StatePublished - Dec 2020

Keywords

  • Acute kidney injury
  • Gut microbiota
  • Ischemia reperfusion
  • Short-chain fatty acids
  • T cells

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

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