Abstract
Acute kidney injury (AKI) is a common and serious syndrome that involves multiple pathophysiologic mechanisms. Recent studies have demonstrated that dysbiosis of the gut microbiota mediates experimental AKI. The precise microbial populations involved and the underlying mechanisms are currently being explored. In this mini-review based on the NIH AKI O'Brien Center symposium of February 2020, we discuss data on gut microbiota in AKI with a focus on the immune system and short-chain fatty acids as mediators of microbiome-kidney crosstalk.
Original language | English (US) |
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Pages (from-to) | 662-664 |
Number of pages | 3 |
Journal | Nephron |
Volume | 144 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2020 |
Keywords
- Acute kidney injury
- Gut microbiota
- Ischemia reperfusion
- Short-chain fatty acids
- T cells
ASJC Scopus subject areas
- Physiology
- Nephrology
- Physiology (medical)
- Urology