TY - JOUR
T1 - Gut microbial metabolites and blood pressure regulation
T2 - Focus on SCFAs and TMAO
AU - Poll, Brian G.
AU - Cheema, Muhammad Umar
AU - Pluznick, Jennifer L.
N1 - Funding Information:
This work was supported by National Institutes of Health Grants F31 HL-144061 (to B.P.), R01 HL-128512 (to J.L.P.), and R01 DK-107726 (to J.L.P.).
Publisher Copyright:
© 2020 Int. Union Physiol. Sci./Am. Physiol. Soc.
PY - 2020/7
Y1 - 2020/7
N2 - Shifts in the gut microbiome play a key role in blood pressure regulation, and changes in the production of gut microbial metabolites are likely to be a key mechanism. Known gut microbial metabolites include short-chain fatty acids, which can signal via G-protein-coupled receptors, and trimethylamine-N ox-ide. In this review, we provide an overview of gut microbial metabolites documented thus far to play a role in blood pressure regulation.
AB - Shifts in the gut microbiome play a key role in blood pressure regulation, and changes in the production of gut microbial metabolites are likely to be a key mechanism. Known gut microbial metabolites include short-chain fatty acids, which can signal via G-protein-coupled receptors, and trimethylamine-N ox-ide. In this review, we provide an overview of gut microbial metabolites documented thus far to play a role in blood pressure regulation.
KW - Blood pressure
KW - G-protein-coupled receptors
KW - Gut microbial metabolite
KW - Hypertension
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U2 - 10.1152/physiol.00004.2020
DO - 10.1152/physiol.00004.2020
M3 - Article
C2 - 32490748
AN - SCOPUS:85085914974
SN - 1548-9213
VL - 35
SP - 275
EP - 284
JO - Physiology
JF - Physiology
IS - 4
ER -