Gut microbial metabolites and blood pressure regulation: Focus on SCFAs and TMAO

Brian G. Poll, Muhammad Umar Cheema, Jennifer L. Pluznick

Research output: Contribution to journalArticlepeer-review

Abstract

Shifts in the gut microbiome play a key role in blood pressure regulation, and changes in the production of gut microbial metabolites are likely to be a key mechanism. Known gut microbial metabolites include short-chain fatty acids, which can signal via G-protein-coupled receptors, and trimethylamine-N ox-ide. In this review, we provide an overview of gut microbial metabolites documented thus far to play a role in blood pressure regulation.

Original languageEnglish (US)
Pages (from-to)275-284
Number of pages10
JournalPhysiology
Volume35
Issue number4
DOIs
StatePublished - Jul 2020

Keywords

  • Blood pressure
  • G-protein-coupled receptors
  • Gut microbial metabolite
  • Hypertension

ASJC Scopus subject areas

  • Physiology

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