Gut healing: Haemocytes aid via Sax and Tkv jazzes it down

Lesley N. Weaver; Daniela Drummond-Barbosa

doi:10.1038/ncb3178

Gut healing: Haemocytes aid via Sax and Tkv jazzes it down

Lesley N. Weaver, Daniela Drummond-Barbosa

Bloomberg School of Public Health

Research output: Contribution to journal › Review article › peer-review

Abstract

Control of stem cell activity is essential for accurate regeneration. Pathogen- or chemical-induced intestinal damage is now shown to recruit haemocytes expressing bone morphogenetic protein signals that stimulate proliferation of intestinal stem cells and subsequently induce their quiescence, in conjunction with muscle-derived bone morphogenetic proteins. A temporal switch in expression of Type I receptors enables this two-phase response.

Original language	English (US)
Pages (from-to)	707-709
Number of pages	3
Journal	Nature cell biology
Volume	17
Issue number	6
DOIs	https://doi.org/10.1038/ncb3178
State	Published - Jun 1 2015

ASJC Scopus subject areas

Cell Biology

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10.1038/ncb3178

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title = "Gut healing: Haemocytes aid via Sax and Tkv jazzes it down",

abstract = "Control of stem cell activity is essential for accurate regeneration. Pathogen- or chemical-induced intestinal damage is now shown to recruit haemocytes expressing bone morphogenetic protein signals that stimulate proliferation of intestinal stem cells and subsequently induce their quiescence, in conjunction with muscle-derived bone morphogenetic proteins. A temporal switch in expression of Type I receptors enables this two-phase response.",

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AB - Control of stem cell activity is essential for accurate regeneration. Pathogen- or chemical-induced intestinal damage is now shown to recruit haemocytes expressing bone morphogenetic protein signals that stimulate proliferation of intestinal stem cells and subsequently induce their quiescence, in conjunction with muscle-derived bone morphogenetic proteins. A temporal switch in expression of Type I receptors enables this two-phase response.

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Gut healing: Haemocytes aid via Sax and Tkv jazzes it down

Abstract

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