TY - JOUR
T1 - Guillain-barré syndrome in Northern China relationship to Campylobacter jejuni infection and anti-glycolipid antibodies
AU - Ho, T. W.
AU - Mishu, B.
AU - Li, C. Y.
AU - Gao, C. Y.
AU - Cornblath, D. R.
AU - Griffin, J. W.
AU - Asbury, A. K.
AU - Blaser, M. J.
AU - Mckhann, G. M.
N1 - Funding Information:
We wish thank Drs Lars Svennerholm and Pamela Fredman for measurement of glycolipid antibodies, Dr Diane Griffin for measurement of measles antibodies, Dr Su Fang Sun for support and encouragement, Dr Pamela Talalay and Rod Graham for editorial assistance and Dr Norman Latov for providing helpful comments. This study was supported by US NIH-NINDS grants RO1-NS31528 and PO1-22849, the Public Health Department of Hebei Province, FIDIA Pharmaceuticals, the AIREN Foundation and the Rockefeller Foundation. Dr Ho was supported by NINDS Special Fellowship NS09286.
Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 1995/6
Y1 - 1995/6
N2 - Guillain-Barré syndrome has been considered to be primarily an acute inflammatory demyelinating polyneuropathy (AIDP). Our experience with Guillain-Barré syndrome in northern China differs from the traditional concept. Electrophysiologically and pathologically, most of our patients have motor axonal degeneration with minimal cellular inflammation, which we have termed 'acute motor axonal neuropathy' (AMAN). The current studies were undertaken to characterize prospectively the clinical, electrophysiological, and serological features of Guillain-Barré syndrome, defined clinically, in northern China. In 1991 and 1992, we characterized by electrodiagnostic criteria 129 Chinese patients with Guillain-Barré syndrome. The AMAN form was present in 65% of patients, the AIDP form in 24% and 11% were unclassifiable. For the 38 patients who presented from January to October, 1992, we performed serological assays for antibodies to Campylobacter jejuni and to glycolipids. Of these 38 patients, 55% had AMAN, 32% had AIDP and 13% were unclassifiable. Sixty-six percent of the 38 had serological evidence of recent C. jejuni infection as compared with 16% of village controls (P = 0.001). Seventy-six percent of AMAN patients and 42% of AIDP patients were seropositive. IgG anti-GMl antibodies were more frequent in Guillain-Barre syndrome patients compared with village controls (42% versus 6%; P < 0.01). However, no statistically significant correlations were found between the pattern of disease, AMAN or AIDP, anti-glycolipid antibodies, or C. jejuni antibodies. Based on electrophysiological criteria, Guillain-Barré syndrome in northern China can be divided into two predominant forms: AIDP and AMAN. The AMAN form is more common and predominates in the yearly summer outbreaks of Guillain-Barre syndrome. In clinically diagnosed Guillain-Barre syndrome in northern China, C. jejuni may play an important role, especially in the AMAN form.
AB - Guillain-Barré syndrome has been considered to be primarily an acute inflammatory demyelinating polyneuropathy (AIDP). Our experience with Guillain-Barré syndrome in northern China differs from the traditional concept. Electrophysiologically and pathologically, most of our patients have motor axonal degeneration with minimal cellular inflammation, which we have termed 'acute motor axonal neuropathy' (AMAN). The current studies were undertaken to characterize prospectively the clinical, electrophysiological, and serological features of Guillain-Barré syndrome, defined clinically, in northern China. In 1991 and 1992, we characterized by electrodiagnostic criteria 129 Chinese patients with Guillain-Barré syndrome. The AMAN form was present in 65% of patients, the AIDP form in 24% and 11% were unclassifiable. For the 38 patients who presented from January to October, 1992, we performed serological assays for antibodies to Campylobacter jejuni and to glycolipids. Of these 38 patients, 55% had AMAN, 32% had AIDP and 13% were unclassifiable. Sixty-six percent of the 38 had serological evidence of recent C. jejuni infection as compared with 16% of village controls (P = 0.001). Seventy-six percent of AMAN patients and 42% of AIDP patients were seropositive. IgG anti-GMl antibodies were more frequent in Guillain-Barre syndrome patients compared with village controls (42% versus 6%; P < 0.01). However, no statistically significant correlations were found between the pattern of disease, AMAN or AIDP, anti-glycolipid antibodies, or C. jejuni antibodies. Based on electrophysiological criteria, Guillain-Barré syndrome in northern China can be divided into two predominant forms: AIDP and AMAN. The AMAN form is more common and predominates in the yearly summer outbreaks of Guillain-Barre syndrome. In clinically diagnosed Guillain-Barre syndrome in northern China, C. jejuni may play an important role, especially in the AMAN form.
KW - Antibodies
KW - Axons
KW - Campylobacter jejuni
KW - Glycolipids
KW - Guillain-Barré syndrome
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U2 - 10.1093/brain/118.3.597
DO - 10.1093/brain/118.3.597
M3 - Article
C2 - 7600081
AN - SCOPUS:0029017652
SN - 0006-8950
VL - 118
SP - 597
EP - 605
JO - Brain
JF - Brain
IS - 3
ER -