TY - JOUR
T1 - Guidelines on genetic evaluation and management of lynch syndrome
T2 - A consensus statement by the US multi-society task force on colorectal cancer
AU - Giardiello, Francis M.
AU - Allen, John I.
AU - Axilbund, Jennifer E.
AU - Boland, C. Richard
AU - Burke, Carol A.
AU - Burt, Randall W.
AU - Church, James M.
AU - Dominitz, Jason A.
AU - Johnson, David A.
AU - Kaltenbach, Tonya
AU - Levin, Theodore R.
AU - Lieberman, David A.
AU - Robertson, Douglas J.
AU - Syngal, Sapna
AU - Rex, Douglas K.
PY - 2014/8
Y1 - 2014/8
N2 - The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision of genetic testing and management of patients at risk for and affected with Lynch syndrome as follows: Figure 1 provides a colorectal cancer risk assessment tool to screen individuals in the office or endoscopy setting; Figure 2 illustrates a strategy for universal screening for Lynch syndrome by tumor testing of patients diagnosed with colorectal cancer; Figures 3,4,5,6 provide algorithms for genetic evaluation of affected and at-risk family members of pedigrees with Lynch syndrome; Table 10 provides guidelines for screening at-risk and affected persons with Lynch syndrome; and Table 12 lists the guidelines for the management of patients with Lynch syndrome. A detailed explanation of Lynch syndrome and the methodology utilized to derive these guidelines, as well as an explanation of, and supporting literature for, these guidelines are provided.
AB - The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision of genetic testing and management of patients at risk for and affected with Lynch syndrome as follows: Figure 1 provides a colorectal cancer risk assessment tool to screen individuals in the office or endoscopy setting; Figure 2 illustrates a strategy for universal screening for Lynch syndrome by tumor testing of patients diagnosed with colorectal cancer; Figures 3,4,5,6 provide algorithms for genetic evaluation of affected and at-risk family members of pedigrees with Lynch syndrome; Table 10 provides guidelines for screening at-risk and affected persons with Lynch syndrome; and Table 12 lists the guidelines for the management of patients with Lynch syndrome. A detailed explanation of Lynch syndrome and the methodology utilized to derive these guidelines, as well as an explanation of, and supporting literature for, these guidelines are provided.
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U2 - 10.1038/ajg.2014.186
DO - 10.1038/ajg.2014.186
M3 - Article
C2 - 25070057
AN - SCOPUS:84905595139
SN - 0002-9270
VL - 109
SP - 1159
EP - 1179
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 8
ER -