@article{7c18a78939e244349b9d1ce64f074841,
title = "Guidelines on genetic evaluation and management of lynch syndrome: A consensus statement by the us multi-society task force on colorectal cancer",
abstract = "The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision of genetic testing and management of patients at risk for and affected with Lynch syndrome as follows: Figure 1 provides a colorectal cancer risk assessment tool to screen individuals in the office or endoscopy setting; Figure 2 illustrates a strategy for universal screening for Lynch syndrome by tumor testing of patients diagnosed with colorectal cancer; Figures 3-6 provide algorithms for genetic evaluation of affected and at-risk family members of pedigrees with Lynch syndrome; Table 10 provides guidelines for screening at-risk and affected persons with Lynch syndrome; and Table 12 lists the guidelines for the management of patients with Lynch syndrome. A detailed explanation of Lynch syndrome and the methodology utilized to derive these guidelines, as well as an explanation of, and supporting literature for, these guidelines are provided.",
keywords = "Colorectal Cancer, Genetic Testing, Lynch Syndrome",
author = "Giardiello, {Francis M.} and Allen, {John I.} and Axilbund, {Jennifer E.} and Boland, {C. Richard} and Burke, {Carol A.} and Burt, {Randall W.} and Church, {James M.} and Dominitz, {Jason A.} and Johnson, {David A.} and Tonya Kaltenbach and Levin, {Theodore R.} and Lieberman, {David A.} and Robertson, {Douglas J.} and Sapna Syngal and Rex, {Douglas K.}",
note = "Funding Information: Conflicts of interest These authors disclose the following: C. Richard Boland and Randall W. Burt are consultants for Myriad Genetic. Jason A. Dominitz received resources in support of this work from the VA Puget Sound Health Care System , Seattle, Washington. The views expressed in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs. David A. Johnson is a clinical investigator for EXACT Sciences, a consultant for Epigenomics, and on the advisory board for Given Imaging. Tonya Kaltenbach is a research grant recipient and consultant for Olympus American Inc. David A. Lieberman is on the advisory board for Given Imaging and Exact Sciences. Douglas J. Robertson is on the advisory board of Given Imaging. Sapna Syngal is an unpaid advisor/collaborator with Myriad genetics and a consultant for Archimedes, Inc. Douglas K. Rex is a consultant for Olympus America, Braintree Laboratories, Ferring Pharmaceuticals, Epigenomics, EXACT Sciences, Given Imaging, received research support from Olympus America; and is on the speaker{\textquoteright}s bureau for Olympus America and Boston Scientific. The remaining authors disclose no conflicts. ",
year = "2014",
month = aug,
doi = "10.1053/j.gastro.2014.04.001",
language = "English (US)",
volume = "147",
pages = "502--526",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "2",
}