Guidance for the evaluation and treatment of hereditary and acquired thrombophilia

Scott M. Stevens, Scott C. Woller, Kenneth A. Bauer, Raj Kasthuri, Mary Cushman, Michael B Streiff, Wendy Lim, James D. Douketis

Research output: Contribution to journalArticle

Abstract

Thrombophilias are hereditary and/or acquired conditions that predispose patients to thrombosis. Testing for thrombophilia is commonly performed in patients with venous thrombosis and their relatives; however such testing usually does not provide information that impacts management and may result in harm. This manuscript, initiated by the Anticoagulation Forum, provides clinical guidance for thrombophilia testing in five clinical situations: following 1) provoked venous thromboembolism, 2) unprovoked venous thromboembolism; 3) in relatives of patients with thrombosis, 4) in female relatives of patients with thrombosis considering estrogen use; and 5) in female relatives of patients with thrombosis who are considering pregnancy. Additionally, guidance is provided regarding the timing of thrombophilia testing. The role of thrombophilia testing in arterial thrombosis and for evaluation of recurrent pregnancy loss is not addressed. Statements are based on existing guidelines and consensus expert opinion where guidelines are lacking. We recommend that thrombophilia testing not be performed in most situations. When performed, it should be used in a highly selective manner, and only in circumstances where the information obtained will influence a decision important to the patient, and outweigh the potential risks of testing. Testing should not be performed during acute thrombosis or during the initial (3-month) period of anticoagulation.

Original languageEnglish (US)
Pages (from-to)154-164
Number of pages11
JournalJournal of Thrombosis and Thrombolysis
Volume41
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Fingerprint

Thrombophilia
Thrombosis
Venous Thromboembolism
Therapeutics
Guidelines
Pregnancy
Information Management
Expert Testimony
Venous Thrombosis
Hereditary Thrombophilia
Consensus
Estrogens

Keywords

  • Antiphospholipid syndrome
  • Hereditary thrombophilia
  • Risk factors
  • Thrombophilia
  • Venous thromboembolism

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

Cite this

Stevens, S. M., Woller, S. C., Bauer, K. A., Kasthuri, R., Cushman, M., Streiff, M. B., ... Douketis, J. D. (2016). Guidance for the evaluation and treatment of hereditary and acquired thrombophilia. Journal of Thrombosis and Thrombolysis, 41(1), 154-164. https://doi.org/10.1007/s11239-015-1316-1

Guidance for the evaluation and treatment of hereditary and acquired thrombophilia. / Stevens, Scott M.; Woller, Scott C.; Bauer, Kenneth A.; Kasthuri, Raj; Cushman, Mary; Streiff, Michael B; Lim, Wendy; Douketis, James D.

In: Journal of Thrombosis and Thrombolysis, Vol. 41, No. 1, 01.01.2016, p. 154-164.

Research output: Contribution to journalArticle

Stevens, SM, Woller, SC, Bauer, KA, Kasthuri, R, Cushman, M, Streiff, MB, Lim, W & Douketis, JD 2016, 'Guidance for the evaluation and treatment of hereditary and acquired thrombophilia', Journal of Thrombosis and Thrombolysis, vol. 41, no. 1, pp. 154-164. https://doi.org/10.1007/s11239-015-1316-1
Stevens, Scott M. ; Woller, Scott C. ; Bauer, Kenneth A. ; Kasthuri, Raj ; Cushman, Mary ; Streiff, Michael B ; Lim, Wendy ; Douketis, James D. / Guidance for the evaluation and treatment of hereditary and acquired thrombophilia. In: Journal of Thrombosis and Thrombolysis. 2016 ; Vol. 41, No. 1. pp. 154-164.
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