@article{f72de4896f6546cf9962320d9eeb0036,
title = "Guidance for the evaluation and treatment of hereditary and acquired thrombophilia",
abstract = "Thrombophilias are hereditary and/or acquired conditions that predispose patients to thrombosis. Testing for thrombophilia is commonly performed in patients with venous thrombosis and their relatives; however such testing usually does not provide information that impacts management and may result in harm. This manuscript, initiated by the Anticoagulation Forum, provides clinical guidance for thrombophilia testing in five clinical situations: following 1) provoked venous thromboembolism, 2) unprovoked venous thromboembolism; 3) in relatives of patients with thrombosis, 4) in female relatives of patients with thrombosis considering estrogen use; and 5) in female relatives of patients with thrombosis who are considering pregnancy. Additionally, guidance is provided regarding the timing of thrombophilia testing. The role of thrombophilia testing in arterial thrombosis and for evaluation of recurrent pregnancy loss is not addressed. Statements are based on existing guidelines and consensus expert opinion where guidelines are lacking. We recommend that thrombophilia testing not be performed in most situations. When performed, it should be used in a highly selective manner, and only in circumstances where the information obtained will influence a decision important to the patient, and outweigh the potential risks of testing. Testing should not be performed during acute thrombosis or during the initial (3-month) period of anticoagulation.",
keywords = "Antiphospholipid syndrome, Hereditary thrombophilia, Risk factors, Thrombophilia, Venous thromboembolism",
author = "Stevens, {Scott M.} and Woller, {Scott C.} and Bauer, {Kenneth A.} and Raj Kasthuri and Mary Cushman and Michael Streiff and Wendy Lim and Douketis, {James D.}",
note = "Funding Information: S Stevens and S Woller: research contracts with Bristol-Myers Squibb and TWINE LLC for execution of clinical trials. K Bauer: consultant for Instrumentation Laboratory. R Kasthuri, M Cushman and W Lim: no relevant conflicts of interest to declare. M Streiff: consulted for Bio2Medical, Boehringer Ingelheim, Daiichi-Sankyo, Janssen and Pfizer and has or will participate in research grants with Portola, Daiichi-Sankyo and Janssen. J Douketis: received honoraria from Actelion, Bayer, Biotie, Boehringer Ingelheim, Bristol Myers Squibb, Daiichi Sankyo, Janssen, Medicines Co., Pfizer, Portola, and Sanofi for consulting and education, and has received research funding from Boehringer Ingelheim. Funding Information: We wish to acknowledge the support provided by Myelin and Associates with the preparation of this manuscript for submission. The work contained in this manuscript was partially funded by support from the following companies: Boehringer Ingelheim, Daiichi Sankyo and Janssen Pharmaceuticals. This guidance document is endorsed by the Anticoagulation Forum{\textquoteright}s Board of Directors: Mark Crowther, MD, MSc, FRCPC, Jack E. Ansell, MD, Allison Burnett, PharmD, Nathan Clark, PharmD, Adam Cuker, MD, David Garcia, MD, Scott Kaatz, DO, MSc, FACP, Renato D. Lopes, MD, PhD, Tracy Minichiello, MD, Edith Nutescu, PharmD, FCCP, Lynn Oertel, MS, ANP, CACP, Eva Kline-Rogers, MS, RN, NP,Terri Schnurr, RN, CCRC, Michael Streiff, MD, Diane Wirth, ANP, CACP, BCPS, CACP, Daniel Witt, Pharm D, Ann Wittkowsky, PharmD, CACP, FASHP, FCCP. Publisher Copyright: {\textcopyright} 2016, The Author(s).",
year = "2016",
month = jan,
day = "1",
doi = "10.1007/s11239-015-1316-1",
language = "English (US)",
volume = "41",
pages = "154--164",
journal = "Journal of Thrombosis and Thrombolysis",
issn = "0929-5305",
publisher = "Springer Netherlands",
number = "1",
}