Guanine nucleotides differentiate agonist and antagonist interactions with opiate receptors

Steven R. Childers, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

Abstract

Opiate receptor binding is regulated by guanine nucleotides differentially for agonists and antagonists. Guanosine-5′-triphosphate (GTP), its stable analogue guanyl-5′-yl-imidodiphosphate (Gpp(NH)p) and GDP inhibit binding of the 3H-agonists dihydromorphine, etorphine and enkephalins but not the 3H-antagonists naloxone or diprenorphine. GMP, ATP, ADP and AMP fail to alter either agonist or antagonist binding. Effects are more pronounced in the presence than in the absence of sodium.

Original languageEnglish (US)
Pages (from-to)759-761
Number of pages3
JournalLife Sciences
Volume23
Issue number7
DOIs
StatePublished - Aug 21 1978

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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