Guanine nucleotides differentiate agonist and antagonist interactions with opiate receptors

Steven R. Childers; Solomon H. Snyder

doi:10.1016/0024-3205(78)90077-2

Guanine nucleotides differentiate agonist and antagonist interactions with opiate receptors

Steven R. Childers, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Opiate receptor binding is regulated by guanine nucleotides differentially for agonists and antagonists. Guanosine-5′-triphosphate (GTP), its stable analogue guanyl-5′-yl-imidodiphosphate (Gpp(NH)p) and GDP inhibit binding of the ³H-agonists dihydromorphine, etorphine and enkephalins but not the ³H-antagonists naloxone or diprenorphine. GMP, ATP, ADP and AMP fail to alter either agonist or antagonist binding. Effects are more pronounced in the presence than in the absence of sodium.

Original language	English (US)
Pages (from-to)	759-761
Number of pages	3
Journal	Life Sciences
Volume	23
Issue number	7
DOIs	https://doi.org/10.1016/0024-3205(78)90077-2
State	Published - Aug 21 1978

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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AU - Snyder, Solomon H.

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AB - Opiate receptor binding is regulated by guanine nucleotides differentially for agonists and antagonists. Guanosine-5′-triphosphate (GTP), its stable analogue guanyl-5′-yl-imidodiphosphate (Gpp(NH)p) and GDP inhibit binding of the 3H-agonists dihydromorphine, etorphine and enkephalins but not the 3H-antagonists naloxone or diprenorphine. GMP, ATP, ADP and AMP fail to alter either agonist or antagonist binding. Effects are more pronounced in the presence than in the absence of sodium.

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