Guanfacine Use in Children with Down Syndrome and Comorbid Attention-Deficit Hyperactivity Disorder (ADHD) with Disruptive Behaviors

George T Capone, Liza Brecher, Mihee Bay

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to characterize children with Down syndrome and attention-deficit hyperactivity disorder (ADHD) with disruptive behaviors using the Aberrant Behavior Checklist (ABC), and to measure the treatment effects of guanfacine on maladaptive behaviors. Subjects were enrolled from a group of outpatients who visited our clinic between 2002 and 2007. Subjects (N = 23) were children with Down syndrome ages 4 to 12 years (mean 7.4 ± 4.1), who met criteria for ADHD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The Aberrant Behavior Checklist Irritability and Hyperactivity subscales each showed a significant decrease (P

Original languageEnglish (US)
Pages (from-to)957-964
Number of pages8
JournalJournal of Child Neurology
Volume31
Issue number8
DOIs
StatePublished - Jul 1 2016

Keywords

  • aggression
  • Alpha-adrenergic agonist
  • attention-deficit hyperactivity disorder (ADHD)
  • disruptive behavior
  • Down syndrome
  • guanfacine
  • intellectual disability

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Fingerprint

Dive into the research topics of 'Guanfacine Use in Children with Down Syndrome and Comorbid Attention-Deficit Hyperactivity Disorder (ADHD) with Disruptive Behaviors'. Together they form a unique fingerprint.

Cite this