Guanfacine Use in Children with Down Syndrome and Comorbid Attention-Deficit Hyperactivity Disorder (ADHD) with Disruptive Behaviors

George T. Capone, Liza Brecher, Mihee Bay

Research output: Research - peer-reviewArticle

Abstract

The purpose of this study was to characterize children with Down syndrome and attention-deficit hyperactivity disorder (ADHD) with disruptive behaviors using the Aberrant Behavior Checklist (ABC), and to measure the treatment effects of guanfacine on maladaptive behaviors. Subjects were enrolled from a group of outpatients who visited our clinic between 2002 and 2007. Subjects (N = 23) were children with Down syndrome ages 4 to 12 years (mean 7.4 ± 4.1), who met criteria for ADHD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The Aberrant Behavior Checklist Irritability and Hyperactivity subscales each showed a significant decrease (P

LanguageEnglish (US)
Pages957-964
Number of pages8
JournalJournal of Child Neurology
Volume31
Issue number8
DOIs
StatePublished - Jul 1 2016

Fingerprint

Guanfacine
Attention Deficit Disorder with Hyperactivity
Down Syndrome
Problem Behavior
Checklist
Diagnostic and Statistical Manual of Mental Disorders
Outpatients
Therapeutics

Keywords

  • aggression
  • Alpha-adrenergic agonist
  • attention-deficit hyperactivity disorder (ADHD)
  • disruptive behavior
  • Down syndrome
  • guanfacine
  • intellectual disability

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Guanfacine Use in Children with Down Syndrome and Comorbid Attention-Deficit Hyperactivity Disorder (ADHD) with Disruptive Behaviors. / Capone, George T.; Brecher, Liza; Bay, Mihee.

In: Journal of Child Neurology, Vol. 31, No. 8, 01.07.2016, p. 957-964.

Research output: Research - peer-reviewArticle

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