Guanfacine Use in Children with Down Syndrome and Comorbid Attention-Deficit Hyperactivity Disorder (ADHD) with Disruptive Behaviors

George T. Capone; Liza Brecher; Mihee Bay

doi:10.1177/0883073816634854

Guanfacine Use in Children with Down Syndrome and Comorbid Attention-Deficit Hyperactivity Disorder (ADHD) with Disruptive Behaviors

George T. Capone, Liza Brecher, Mihee Bay

Kennedy Krieger Institute

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The purpose of this study was to characterize children with Down syndrome and attention-deficit hyperactivity disorder (ADHD) with disruptive behaviors using the Aberrant Behavior Checklist (ABC), and to measure the treatment effects of guanfacine on maladaptive behaviors. Subjects were enrolled from a group of outpatients who visited our clinic between 2002 and 2007. Subjects (N = 23) were children with Down syndrome ages 4 to 12 years (mean 7.4 ± 4.1), who met criteria for ADHD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The Aberrant Behavior Checklist Irritability and Hyperactivity subscales each showed a significant decrease (P

Original language	English (US)
Pages (from-to)	957-964
Number of pages	8
Journal	Journal of Child Neurology
Volume	31
Issue number	8
DOIs	https://doi.org/10.1177/0883073816634854
State	Published - Jul 1 2016

Keywords

aggression
Alpha-adrenergic agonist
attention-deficit hyperactivity disorder (ADHD)
disruptive behavior
Down syndrome
guanfacine
intellectual disability

ASJC Scopus subject areas

Clinical Neurology
Pediatrics, Perinatology, and Child Health

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10.1177/0883073816634854

Cite this

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Guanfacine Use in Children with Down Syndrome and Comorbid Attention-Deficit Hyperactivity Disorder (ADHD) with Disruptive Behaviors

Abstract

Keywords

ASJC Scopus subject areas

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