Guanethidine in the Management of Hypertension

L. R. Barker, Alan S. Nies, Raymond L. Woosley

Research output: Contribution to journalLetterpeer-review


To the Editor: Woosley and Nies have provided a very helpful update of the pharmacologic properties of guanethidine (N Engl J Med 295:1053, 1976), but they have not provided an update of its role in the management of hypertension. It is important to note that post-exercise pressures were not measured in the two clinical reports cited by Woosley and Nies.12 I have monitored the use of guanethidine at Baltimore City Hospital since 1971 and have concluded that, because of stereotyped post-exercise orthostatic hypotension, guanethidine should not be administered to obtain a normal resting blood pressure in any hypertensive patient.

Original languageEnglish (US)
Pages (from-to)284-285
Number of pages2
JournalNew England Journal of Medicine
Issue number5
StatePublished - Feb 3 1977

ASJC Scopus subject areas

  • Medicine(all)


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