Growth standards of infants with Prader-Willi syndrome

Merlin G. Butler, Jennifer Sturich, Jaehoon Lee, Susan E. Myers, Barbara Y. Whitman, June Anne Gold, Virginia Kimonis, Ann Scheimann, Norma Terrazas, Daniel J. Driscoll

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To generate and report standardized growth curves for weight, length, head circumference, weight/length, and BMI for non-growth hormone - treated white infants (boys and girls) with Prader-Willi syndrome (PWS) between 0 and 36 months of age. The goal was to monitor growth and compare data with other infants with PWS. METHODS: Anthropometric measures (N = 758) were obtained according to standard methods and analyzed from 186 non - growth hormone - treated white infants (108 boys and 78 girls) with PWS between 0 and 36 months of age. Standardized growth curves were developed and the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentiles were calculated by using the LMS (refers to λ, μ, and σ) smoothing procedure method for weight, length, head circumference, weight/length, and BMI along with the normative 50th percentile using Centers for Disease Control and Prevention national growth data from 2003. The data were plotted for comparison purposes. RESULTS: Five separate standardized growth curves (weight, length, head circumference, weight/length, and BMI) representing 7 percentile ranges were developed from 186 non - growth hormone - treated white male and female infants with PWS aged 0 to 36 months, and the normative 50th percentile was plotted on each standardized infant growth curve. CONCLUSIONS: We encourage the use of these growth standards when examining infants with PWS and evaluating growth for comparison purposes, monitoring for growth patterns, nutritional assessment, and recording responses to growth hormone therapy, commonly used in infants and children with PWS.

Original languageEnglish (US)
Pages (from-to)687-695
Number of pages9
JournalPediatrics
Volume127
Issue number4
DOIs
StatePublished - Apr 1 2011

Keywords

  • Growth hormone therapy
  • Obesity
  • Prader-Willi syndrome
  • Standardized growth curves

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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  • Cite this

    Butler, M. G., Sturich, J., Lee, J., Myers, S. E., Whitman, B. Y., Gold, J. A., Kimonis, V., Scheimann, A., Terrazas, N., & Driscoll, D. J. (2011). Growth standards of infants with Prader-Willi syndrome. Pediatrics, 127(4), 687-695. https://doi.org/10.1542/peds.2010-2736