Growth patterns in early childhood and final attained stature: Data from five birth cohorts from low-and middle-income countries

Aryeh D. Stein, Meng Wang, Reynaldo Martorell, Shane A. Norris, Linda S. Adair, Isabelita Bas, Harshpal Singh Sachdev, Santosh K. Bhargava, Caroline H D Fall, Denise P. Gigante, Cesar G. Victora

Research output: Contribution to journalArticle

Abstract

Growth failure is cumulative, and short stature is associated with multiple indices of reduced human capital. Few studies have been able to address in a single analysis both consideration of the timing of growth failure and comparison across populations. We analyzed data from birth cohorts in Brazil, Guatemala, India, the Philippines, and South Africa (n = 4,659). We used data on length at birth (available for three of the five cohorts), 12 mo, 24 mo, and mid-childhood to construct cohort-and sex-specific conditional length measures. We modeled adult height as a function of conditional length in childhood. The five cohorts experienced varying degrees of growth failure. As adults, the Brazil sample was 0.35 ± 0.89 standard deviations (SD) below the World Health Organization reference, while adult Guatemalans were 1.91 ± 0.87 SD below the reference. All five cohorts experienced a nadir in height for age Z-score at 24 mo. Birth length (in the three cohorts with this variable), and conditional length at 12 mo (in all five cohorts) were the most strongly associated with adult height. Growth in the periods 12-24 mo and 24 mo to mid-childhood showed inconsistent patterns across tertiles of adult height. Despite variation in the magnitude of cumulative growth failure across cohorts, the five cohorts show highly consistent age-specific associations with adult stature. Growth failure prior to age 12 mo was most strongly associated with adult stature. These consistencies speak to the importance of interventions to address intrauterine growth failure and growth failure in the first 12 mo of life.

Original languageEnglish (US)
Pages (from-to)353-359
Number of pages7
JournalAmerican Journal of Human Biology
Volume22
Issue number3
DOIs
StatePublished - May 2010
Externally publishedYes

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childhood
income
Parturition
Growth
Brazil
Epidemiologic Effect Modifiers
Guatemala
World Health Organization
Philippines
nadir
human capital
South Africa
WHO
India
Economics
gender
Population

ASJC Scopus subject areas

  • Anthropology
  • Anatomy
  • Genetics
  • Ecology, Evolution, Behavior and Systematics

Cite this

Growth patterns in early childhood and final attained stature : Data from five birth cohorts from low-and middle-income countries. / Stein, Aryeh D.; Wang, Meng; Martorell, Reynaldo; Norris, Shane A.; Adair, Linda S.; Bas, Isabelita; Sachdev, Harshpal Singh; Bhargava, Santosh K.; Fall, Caroline H D; Gigante, Denise P.; Victora, Cesar G.

In: American Journal of Human Biology, Vol. 22, No. 3, 05.2010, p. 353-359.

Research output: Contribution to journalArticle

Stein, AD, Wang, M, Martorell, R, Norris, SA, Adair, LS, Bas, I, Sachdev, HS, Bhargava, SK, Fall, CHD, Gigante, DP & Victora, CG 2010, 'Growth patterns in early childhood and final attained stature: Data from five birth cohorts from low-and middle-income countries', American Journal of Human Biology, vol. 22, no. 3, pp. 353-359. https://doi.org/10.1002/ajhb.20998
Stein, Aryeh D. ; Wang, Meng ; Martorell, Reynaldo ; Norris, Shane A. ; Adair, Linda S. ; Bas, Isabelita ; Sachdev, Harshpal Singh ; Bhargava, Santosh K. ; Fall, Caroline H D ; Gigante, Denise P. ; Victora, Cesar G. / Growth patterns in early childhood and final attained stature : Data from five birth cohorts from low-and middle-income countries. In: American Journal of Human Biology. 2010 ; Vol. 22, No. 3. pp. 353-359.
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