Hormônio do crescimento ou somatotrófico: novas perspectivas na deficiência isolada de GH a partir da descrição da mutação no gene do receptor do GHRH nos indivíduos da cidade de Itabaianinha, Brasil.

Translated title of the contribution: Growth or somatotrophic hormone: new perspectives in isolated GH deficiency after description of the mutation in the GHRH receptor gene in individuals of Itabaianinha County, Brazil

Anita Hermínia O. Souza, Roberto Salvatori, Carlos E. Martinelli, Walter M.O. Carvalho, Carlos A. Menezes, Elenilde S.de A. Barretto, José A.S. Barreto Filho, Marta R.S.de Alcântara, Carla R.P. Oliveira, Paula R.S.de Alcântara, Roberto J.R. Ramalho, Hélio A. Oliveira, Ivana B.de Lima, Jamille N. Carneiro, Marcos M. Santos, Matthew S. Gill, Peter E. Clayton, Manuel H.A. Oliveira

Research output: Contribution to journalArticlepeer-review

Abstract

In addition to stimulating body growth, growth or somatotrophic hormone plays an important role in metabolism, body composition, lipid profile, cardiovascular status and longevity. Its control is multiregulated by hormones, metabolites and hypothalamic peptides. Obtained data of the isolated growth hormone deficiency (IGHD) after the description of the IVS1+1G-->A GHRH receptor gene mutation in individuals of Itabaianinha County are reviewed. New perspectives about the growth hormone resistance model, the importance of GHRH in the control of GH secretion, the frequency of GHRH-R gene mutations, the diagnostic relevance of IGF-I and the metabolic, cardiovascular and quality of life findings are approached.

Translated title of the contributionGrowth or somatotrophic hormone: new perspectives in isolated GH deficiency after description of the mutation in the GHRH receptor gene in individuals of Itabaianinha County, Brazil
Original languagePortuguese
Pages (from-to)406-413
Number of pages8
JournalArquivos brasileiros de endocrinologia e metabologia
Volume48
Issue number3
DOIs
StatePublished - Jun 2004
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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