Abstract
Multiple signaling pathways mediate the diverse effects of growth hormone (GH) on growth and metabolism. The interaction of GH with GH receptors (GHR) on target cells promotes the association of the cellular tyrosine kinase JAK2 with the GHR, initiating tyrosine phosphorylation of GHR and JAK2, and activation of multiple signaling cascades. GH-stimulated activation of signal transducers and activators of transcription (STATs), mitogen activated protein kinase (MAPK) and phosphatidylinositol 3′ kinase (PI3K) cascades have been shown to regulate the transcription of GH-responsive genes. Cross-talk among these signaling cascades in regulating specific genes suggests that GH signaling to the nucleus involves a GH-regulated signaling network.
Original language | English (US) |
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Pages (from-to) | 771-786 |
Number of pages | 16 |
Journal | Journal of Pediatric Endocrinology and Metabolism |
Volume | 15 |
Issue number | 6 |
DOIs | |
State | Published - 2002 |
Externally published | Yes |
Keywords
- Cytokine receptor family
- GH receptor
- Gene transcription
- JAK2
- MAPK
- PI3K
- SOCS/CIS
- STATs
- Tyrosine kinase
- Tyrosine phosphatase
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Endocrinology, Diabetes and Metabolism
- Endocrinology