Growth hormone signal transduction

Graciela Piwien-Pilipuk, Jeffrey S. Huo, Jessica Schwartz

Research output: Contribution to journalReview articlepeer-review

Abstract

Multiple signaling pathways mediate the diverse effects of growth hormone (GH) on growth and metabolism. The interaction of GH with GH receptors (GHR) on target cells promotes the association of the cellular tyrosine kinase JAK2 with the GHR, initiating tyrosine phosphorylation of GHR and JAK2, and activation of multiple signaling cascades. GH-stimulated activation of signal transducers and activators of transcription (STATs), mitogen activated protein kinase (MAPK) and phosphatidylinositol 3′ kinase (PI3K) cascades have been shown to regulate the transcription of GH-responsive genes. Cross-talk among these signaling cascades in regulating specific genes suggests that GH signaling to the nucleus involves a GH-regulated signaling network.

Original languageEnglish (US)
Pages (from-to)771-786
Number of pages16
JournalJournal of Pediatric Endocrinology and Metabolism
Volume15
Issue number6
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Cytokine receptor family
  • GH receptor
  • Gene transcription
  • JAK2
  • MAPK
  • PI3K
  • SOCS/CIS
  • STATs
  • Tyrosine kinase
  • Tyrosine phosphatase

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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