Growth hormone regulated gene expression.

J. Schwartz, J. S. Huo, G. Piwien-Pilipuk

Research output: Contribution to journalReview article

Abstract

Growth hormone (GH) regulated gene expression contributes to many of the effects of GH on cellular metabolism, growth and differentiation. Study of model systems has revealed several mechanisms by which GH regulates gene expression. Regulation of expression of the proto-oncogene c-fos involves STAT-, MAPK, and PI-3K-mediated changes in transcripton factors. STAT 5 plays important roles in regulation of spi 2.1 expression and in the sexually dimorphic expression of some liver genes. GH-regulated STAT 5 has also been implicated in regulation of other physiologically important genes, including those encoding components of the IGF-I axis and insulin. Together, these studies provide insight into GH signaling mechanisms and diverse physiological roles of GH.

Original languageEnglish (US)
Pages (from-to)231-241
Number of pages11
JournalMinerva endocrinologica
Volume27
Issue number4
StatePublished - Dec 2002
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Schwartz, J., Huo, J. S., & Piwien-Pilipuk, G. (2002). Growth hormone regulated gene expression. Minerva endocrinologica, 27(4), 231-241.