Growth-Factor Nanocapsules That Enable Tunable Controlled Release for Bone Regeneration

Haijun Tian, Juanjuan Du, Jing Wen, Yang Liu, Scott R. Montgomery, Trevor P. Scott, Bayan Aghdasi, Chengjie Xiong, Akinobu Suzuki, Tetsuo Hayashi, Monchai Ruangchainikom, Kevin Phan, Gil Weintraub, Alobaidaan Raed, Samuel S. Murray, Michael D. Daubs, Xianjin Yang, Xu Bo Yuan, Jeffrey C. Wang, Yunfeng Lu

Research output: Contribution to journalArticle

Abstract

Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited by the short in vivo half-lives and the narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. In this research, a nanoscale controlled release system (degradable protein nanocapsule) is established via in situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition. Improved therapeutic outcomes can be achieved with growth factor nanocapsules, as illustrated in spinal cord fusion mediated by bone morphogenetic protein-2 nanocapsules.

Original languageEnglish (US)
Pages (from-to)7362-7369
Number of pages8
JournalACS Nano
Volume10
Issue number8
DOIs
StatePublished - Aug 23 2016

Keywords

  • bone regeneration
  • controlled release
  • degradable polymer
  • inflammation
  • protein nanocapsule

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Fingerprint Dive into the research topics of 'Growth-Factor Nanocapsules That Enable Tunable Controlled Release for Bone Regeneration'. Together they form a unique fingerprint.

  • Cite this

    Tian, H., Du, J., Wen, J., Liu, Y., Montgomery, S. R., Scott, T. P., Aghdasi, B., Xiong, C., Suzuki, A., Hayashi, T., Ruangchainikom, M., Phan, K., Weintraub, G., Raed, A., Murray, S. S., Daubs, M. D., Yang, X., Yuan, X. B., Wang, J. C., & Lu, Y. (2016). Growth-Factor Nanocapsules That Enable Tunable Controlled Release for Bone Regeneration. ACS Nano, 10(8), 7362-7369. https://doi.org/10.1021/acsnano.5b07950