Growth-factor enhancement of compromised gut function following massive small-bowel resection

Marshall Z. Schwartz, Yoshifumi Kato, Dahong Yu, Jeff R. Lukish

Research output: Contribution to journalArticle

Abstract

Our laboratory has shown that epidermal growth factor (EGF) and hepatocyte growth factor (HGF) can improve the function of normal rat small intestine. This study was designed to evaluate the role of these growth factors on the residual small intestine following massive (80%) small bowel resection. Our data demonstrate that EGF and HGF can enhance intestinal substrate absorption and mucosal mass beyond that which occurs with intestinal adaptation. These growth factors may be beneficial in the management of children with short bowel syndrome.

Original languageEnglish (US)
Pages (from-to)174-175
Number of pages2
JournalPediatric Surgery International
Volume16
Issue number3
StatePublished - Mar 2000
Externally publishedYes

Keywords

  • Epidermal growth factor
  • Growth factor
  • Hepatocyte growth factor
  • Intestinal function
  • Intestinal proliferation
  • Short bowel syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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