TY - JOUR
T1 - Growth factor-eluting technologies for bone tissue engineering
AU - Nyberg, Ethan
AU - Holmes, Christina
AU - Witham, Timothy
AU - Grayson, Warren L.
N1 - Publisher Copyright:
© 2015, Controlled Release Society.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Growth factors are essential orchestrators of the normal bone fracture healing response. For non-union defects, delivery of exogenous growth factors to the injured site significantly improves healing outcomes. However, current clinical methods for scaffold-based growth factor delivery are fairly rudimentary, and there is a need for greater spatial and temporal regulation to increase their in vivo efficacy. Various approaches used to provide spatiotemporal control of growth factor delivery from bone tissue engineering scaffolds include physical entrapment, chemical binding, surface modifications, biomineralization, micro- and nanoparticle encapsulation, and genetically engineered cells. Here, we provide a brief review of these technologies, describing the fundamental mechanisms used to regulate release kinetics. Examples of their use in pre-clinical studies are discussed, and their capacities to provide tunable, growth factor delivery are compared. These advanced scaffold systems have the potential to provide safer, more effective therapies for bone regeneration than the systems currently employed in the clinic.
AB - Growth factors are essential orchestrators of the normal bone fracture healing response. For non-union defects, delivery of exogenous growth factors to the injured site significantly improves healing outcomes. However, current clinical methods for scaffold-based growth factor delivery are fairly rudimentary, and there is a need for greater spatial and temporal regulation to increase their in vivo efficacy. Various approaches used to provide spatiotemporal control of growth factor delivery from bone tissue engineering scaffolds include physical entrapment, chemical binding, surface modifications, biomineralization, micro- and nanoparticle encapsulation, and genetically engineered cells. Here, we provide a brief review of these technologies, describing the fundamental mechanisms used to regulate release kinetics. Examples of their use in pre-clinical studies are discussed, and their capacities to provide tunable, growth factor delivery are compared. These advanced scaffold systems have the potential to provide safer, more effective therapies for bone regeneration than the systems currently employed in the clinic.
KW - Biomaterials
KW - Bone scaffold
KW - Osteogenesis
KW - Stem cells
KW - Tissue engineering
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U2 - 10.1007/s13346-015-0233-3
DO - 10.1007/s13346-015-0233-3
M3 - Article
C2 - 25967594
AN - SCOPUS:84960121182
SN - 2190-393X
VL - 6
SP - 184
EP - 194
JO - Drug Delivery and Translational Research
JF - Drug Delivery and Translational Research
IS - 2
ER -