Growth factor-eluting technologies for bone tissue engineering

Ethan Nyberg, Christina Holmes, Timothy Witham, Warren L. Grayson

Research output: Contribution to journalArticle

Abstract

Growth factors are essential orchestrators of the normal bone fracture healing response. For non-union defects, delivery of exogenous growth factors to the injured site significantly improves healing outcomes. However, current clinical methods for scaffold-based growth factor delivery are fairly rudimentary, and there is a need for greater spatial and temporal regulation to increase their in vivo efficacy. Various approaches used to provide spatiotemporal control of growth factor delivery from bone tissue engineering scaffolds include physical entrapment, chemical binding, surface modifications, biomineralization, micro- and nanoparticle encapsulation, and genetically engineered cells. Here, we provide a brief review of these technologies, describing the fundamental mechanisms used to regulate release kinetics. Examples of their use in pre-clinical studies are discussed, and their capacities to provide tunable, growth factor delivery are compared. These advanced scaffold systems have the potential to provide safer, more effective therapies for bone regeneration than the systems currently employed in the clinic.

Original languageEnglish (US)
Pages (from-to)184-194
Number of pages11
JournalDrug Delivery and Translational Research
Volume6
Issue number2
DOIs
StatePublished - Apr 1 2016

Keywords

  • Biomaterials
  • Bone scaffold
  • Osteogenesis
  • Stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • Pharmaceutical Science

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