Growth factor control of extracellular proteolysis

D. B. Rifkin, D. Moscatelli, J. Bizik, N. Quarto, F. Blei, P. Dennis, R. Flaumenhaft, P. Mignatti

Research output: Contribution to journalArticlepeer-review


The involvement of proteases and growth factors in angiogenesis is complex. The angiogenic factor basic fibroblast growth factor (bFGF) induces increased synthesis of both plasminogen activator and collagenase in endothelial cells. In addition, bFGF increases the number of plasminogen activator receptors on the cell surface. Increased production of plasmin may be responsible for the release of soluble complexes of heparan sulfate-bFGF which may be the active form of bFGF. The activity of a negative regulator of angiogenesis, transforming growth factor β (TGF-β), is also regulated by proteases since the released latent form of TGF-β is activated by a surface proteolytic assembly plasminogen activator and plasmin. Since TGF-β induces an inhibitor of plasminogen activator, the activation reaction is self-regulatory.

Original languageEnglish (US)
Pages (from-to)313-318
Number of pages6
JournalCell Differentiation and Development
Issue number3
StatePublished - Dec 11 1990


  • Extracellular proteolysis
  • Growth factor control

ASJC Scopus subject areas

  • Developmental Biology


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