Growth differentiation factor-15 as a biomarker of strength and recovery in survivors of acute respiratory failure

Brian J. Rosenberg, Michio Hirano, Catarina M. Quinzii, Elizabeth Ann Colantuoni, Dale Needham, David J. Lederer, Matthew R. Baldwin

Research output: Contribution to journalArticle

Abstract

Muscle mitochondrial dysfunction is implicated in intensive care unit-acquired weakness, but there is no serum biomarker of muscle mitochondrial function for critical illness survivors. Higher serum growth differentiation factor-15 (GDF-15) is a biomarker of inherited mitochondrial myopathy disease and is associated with mortality in several age-related diseases. Among 142 older (age ≥65 years) survivors of acute respiratory failure, we found that higher serum GDF-15 measured during the week prior to hospital discharge was cross-sectionally associated with weaker diaphragm, limb and hand-grip strength, and longitudinally associated with lower rates of functional recovery over 6 months, independent of age, sex, pre-existing disability, comorbidity, frailty, Acute Physiology and Chronic Health Evaluation II scores and concurrent interleukin-6 levels.

Original languageEnglish (US)
JournalThorax
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Growth Differentiation Factor 15
Respiratory Insufficiency
Survivors
Biomarkers
Hand Strength
Serum
Mitochondrial Myopathies
Mitochondrial Diseases
Muscles
APACHE
Diaphragm
Critical Illness
Intensive Care Units
Comorbidity
Interleukin-6
Extremities
Mortality

Keywords

  • Critical Care
  • Not Applicable
  • Pulmonary Rehabilitation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Growth differentiation factor-15 as a biomarker of strength and recovery in survivors of acute respiratory failure. / Rosenberg, Brian J.; Hirano, Michio; Quinzii, Catarina M.; Colantuoni, Elizabeth Ann; Needham, Dale; Lederer, David J.; Baldwin, Matthew R.

In: Thorax, 01.01.2019.

Research output: Contribution to journalArticle

Rosenberg, Brian J. ; Hirano, Michio ; Quinzii, Catarina M. ; Colantuoni, Elizabeth Ann ; Needham, Dale ; Lederer, David J. ; Baldwin, Matthew R. / Growth differentiation factor-15 as a biomarker of strength and recovery in survivors of acute respiratory failure. In: Thorax. 2019.
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AU - Baldwin, Matthew R.

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