Growth cones and the cues that repel them

Research output: Contribution to journalReview articlepeer-review

Abstract

Neuronal growth cones establish appropriate connections with their targets during development by responding to both positive and negative guidance cues. The importance of repulsive and inhibitory cues in pathfinding and target selection has now been firmly established at the cellular and molecular levels. Observations in vitro have demonstrated developmentally significant repulsive interactions among various neuronal populations, providing the basis for molecular and functional characterization of several families of molecules that can mediate these guidance events. Analysis of both the expression and function of these molecules in vivo suggests how they, together with positive guidance cues, participate in the dynamic process of growth-cone guidance during both development and axonal regeneration.

Original languageEnglish (US)
Pages (from-to)507-513
Number of pages7
JournalTrends in neurosciences
Volume19
Issue number11
DOIs
StatePublished - Nov 1996

ASJC Scopus subject areas

  • Neuroscience(all)

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