Growth and neurodevelopmental outcomes after early low-dose hydrocortisone treatment in extremely low birth weight infants

Kristi L. Watterberg, Michele L. Shaffer, Mary J. Mishefske, Corinne L. Leach, Mark C. Mammel, Robert J. Couser, Soraya Abbasi, Cynthia H. Cole, Susan W Aucott, Elizabeth H. Thilo, Henry J. Rozycki, Conra Backstrom Lacy

Research output: Contribution to journalArticle

Abstract

BACKGROUND. Low cortisol concentrations in premature infants have been correlated with increased severity of illness, hypotension, mortality, and development of bronchopulmonary dysplasia. A total of 360 mechanically ventilated infants with a birth weight of 500 to 999 g were enrolled in a randomized, multicenter trial of prophylaxis of early adrenal insufficiency to prevent bronchopulmonary dysplasia. Mortality and bronchopulmonary dysplasia were decreased in the hydrocortisone-treated patients exposed to chorioamnionitis. We now report outcomes at 18 to 22 months' corrected age. PATIENTS AND METHODS. Surviving infants were evaluated with standardized neurologic examination and Bayley Scales of Infant Development-II. Neurodevelopmental impairment was defined as a Mental Developmental Index or Psychomotor Developmental Index of

Original languageEnglish (US)
Pages (from-to)40-48
Number of pages9
JournalPediatrics
Volume120
Issue number1
DOIs
Publication statusPublished - Jul 2007

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Keywords

  • Cerebral palsy
  • Developmental assessment
  • Extremely preterm infant
  • Hydrocortisone
  • Postnatal steroid therapy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Watterberg, K. L., Shaffer, M. L., Mishefske, M. J., Leach, C. L., Mammel, M. C., Couser, R. J., ... Lacy, C. B. (2007). Growth and neurodevelopmental outcomes after early low-dose hydrocortisone treatment in extremely low birth weight infants. Pediatrics, 120(1), 40-48. https://doi.org/10.1542/peds.2006-3158