Group-wise analysis on myelination profiles of cerebral cortex using the second eigenvector of Laplace-Beltrami operator

Seung Goo Kim, Johannes Stelzer, Pierre Louis Bazin, Adrian Viehweger, Thomas Knösche

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Myeloarchitecture of cerebral cortex has crucial implication on the function of cortical columnar modules. Based on the recent development of high-field magnetic resonance imaging (MRI), it was demonstrated that it is possible to individually reconstruct such intracortical microstructures. However, there is a scarcity of publicly available frameworks to perform group-wise statistical inferences on high resolution data. In this paper, we present a novel framework that parameterizes curved brain structures in order to construct correspondences across subjects without deforming individual geometry. We use the second Laplace-Beltrami eigenfunction to build such a parameterization, which is known to monotonically increase along the longest geodesic distance on an arbitrary manifold. To demonstrate our framework, a study on the lateralization of Heschl's gyrus is presented with multiple comparison correction.

Original languageEnglish (US)
Title of host publication2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1007-1010
Number of pages4
ISBN (Electronic)9781467319591
DOIs
StatePublished - Jul 29 2014
Event2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014 - Beijing, China
Duration: Apr 29 2014May 2 2014

Publication series

Name2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014

Other

Other2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014
Country/TerritoryChina
CityBeijing
Period4/29/145/2/14

Keywords

  • Cortical profile
  • Heschl's gyrus
  • Laplace-Beltrami operator
  • Lateralization
  • Myeloarchitecture
  • Quantitative MRI
  • Shape parametrization

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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