Group study of simulated driving fMRI data by multiset canonical correlation analysis

Yi Ou Li, Tom Eichele, Vince D. Calhoun, Tulay Adali

Research output: Contribution to journalArticlepeer-review

Abstract

In this work, we apply a novel statistical method, multiset canonical correlation analysis (M-CCA), to study a group of functional magnetic resonance imaging (fMRI) datasets acquired during simulated driving task. The M-CCA method jointly decomposes fMRI datasets from different subjects/sessions into brain activation maps and their associated time courses, such that the correlation in each group of estimated activation maps across datasets is maximized. Therefore, the functional activations across all datasets are extracted in the order of consistency across different dataset. On the other hand, M-CCA preserves the uniqueness of the functional maps estimated from each dataset by avoiding concatenation of different datasets in the analysis. Hence, the cross-dataset variation of the functional activations can be used to test the hypothesis of functional-behavioral association. In this work, we study 120 simulated driving fMRI datasets and identify parietal-occipital regions and frontal lobe as the most consistently engaged areas across all the subjects and sessions during simulated driving. The functional-behavioral association study indicates that all the estimated brain activations are significantly correlated with the steering operation during the driving task. M-CCA thus provides a new approach to investigate the complex relationship between the brain functions and multiple behavioral variables, especially in naturalistic tasks as demonstrated by the simulated driving study.

Original languageEnglish (US)
Pages (from-to)31-48
Number of pages18
JournalJournal of Signal Processing Systems
Volume68
Issue number1
DOIs
StatePublished - Jul 2012

Keywords

  • Blind source separation
  • Canonical correlation analysis
  • Functional behavioral association
  • Simulated driving
  • fMRI

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Theoretical Computer Science
  • Signal Processing
  • Information Systems
  • Modeling and Simulation
  • Hardware and Architecture

Fingerprint Dive into the research topics of 'Group study of simulated driving fMRI data by multiset canonical correlation analysis'. Together they form a unique fingerprint.

Cite this