Group sequential tests with censored survival data adjusting for covariates

Anastasios A. Tsiatis, Gary L. Rosner, David L. Tritchler

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Group sequential tests for the analysis of survival data that compare two treatments and allow for the adjustment of other concomitant variables are discussed. These methods allow early termination of a study if large treatment differences occur. Based on simulation results, we compare the operating characteristics of these adjusted tests with the unadjusted sequentially-computed log rank test.

Original languageEnglish (US)
Pages (from-to)365-373
Number of pages9
Issue number2
StatePublished - Aug 1985
Externally publishedYes


  • Asymptotic normality
  • Counting process
  • Covariate
  • Group sequential test
  • Survival analysis

ASJC Scopus subject areas

  • Statistics and Probability
  • Mathematics(all)
  • Agricultural and Biological Sciences (miscellaneous)
  • Agricultural and Biological Sciences(all)
  • Statistics, Probability and Uncertainty
  • Applied Mathematics


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