TY - JOUR
T1 - Group analysis identifies differentially elevated biomarkers with distinct outcomes for advanced acute kidney injury in cardiac surgery
AU - Lin, Haiqun
AU - Scherzer, Rebecca
AU - Philbrook, Heather Thiessen
AU - Coca, Steven G.
AU - Wilson, Francis Perry
AU - Garg, Amit X.
AU - Shlipak, Michael G.
AU - Parikh, Chirag R.
N1 - Funding Information:
This work is partially supported by NIH grant R01HL-085757. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
Publisher Copyright:
© 2017 2017 Future Medicine Ltd.
PY - 2017/12
Y1 - 2017/12
N2 - Aim: To investigate early postoperative biomarkers for risk discrimination of advanced acute kidney injury (AKI). Materials & methods: Postoperative plasma biomarkers including NGAL, h-FABP, CK-MB, hsTNT, NT-proBNP, IL-6, IL-10 and VEGF were analyzed using group-based method among 426 patients with AKI after cardiac surgery. Results: Six patient groups with distinct biomarker patterns were identified. Individual biomarker displayed significant difference across the groups. The groups showed better discrimination for advanced AKI than any single biomarker either with or without adjusting for clinical variables. Average concentration of a single biomarker within each group, mortality and risk of a secondary outcome all demonstrated an approximately U-shaped relationship with proportion of advanced AKI within each group. Conclusion: The group-based analysis revealed that the order of the patient groups with an increasing likelihood of advanced AKI had a nonlinear relationship with average concentration of an individual biomarker, mortality and risk of other outcomes.
AB - Aim: To investigate early postoperative biomarkers for risk discrimination of advanced acute kidney injury (AKI). Materials & methods: Postoperative plasma biomarkers including NGAL, h-FABP, CK-MB, hsTNT, NT-proBNP, IL-6, IL-10 and VEGF were analyzed using group-based method among 426 patients with AKI after cardiac surgery. Results: Six patient groups with distinct biomarker patterns were identified. Individual biomarker displayed significant difference across the groups. The groups showed better discrimination for advanced AKI than any single biomarker either with or without adjusting for clinical variables. Average concentration of a single biomarker within each group, mortality and risk of a secondary outcome all demonstrated an approximately U-shaped relationship with proportion of advanced AKI within each group. Conclusion: The group-based analysis revealed that the order of the patient groups with an increasing likelihood of advanced AKI had a nonlinear relationship with average concentration of an individual biomarker, mortality and risk of other outcomes.
KW - advanced AKI
KW - biomarkers of AKI
KW - group-based analysis
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U2 - 10.2217/bmm-2017-0060
DO - 10.2217/bmm-2017-0060
M3 - Article
C2 - 29172665
AN - SCOPUS:85038354669
SN - 1752-0363
VL - 11
SP - 1091
EP - 1102
JO - Biomarkers in Medicine
JF - Biomarkers in Medicine
IS - 12
ER -