TY - JOUR
T1 - Gross placental measures and childhood growth
AU - Baptiste-Roberts, Kesha
AU - Salafia, Carolyn M.
AU - Nicholson, Wanda K.
AU - Duggan, Anne
AU - Wang, Nae Yuh
AU - Brancati, Frederick L.
N1 - Funding Information:
The authors are grateful to Dr. Janet Hardy, an original principal investigator of the Collaborative Perinatal Project who gave invaluable insight and perspective to overall design and conduct of the study. The authors also acknowledge Mr. Archibald Fobbs for his assistance with locating archived documentation. The authors are supported by the National Institutes of Health. KBR is supported by the National Heart, Lung and Blood Institute (T32-HL07024). CMS is supported by K23-MH067857. NW is supported by National Institutes of Health (M01-RR02719) FLB is supported by the National Institute for Diabetes and Digestive and Kidney Disease (K24-DK62222).
PY - 2009/1
Y1 - 2009/1
N2 - Objectives. We hypothesised that the gross placental measures would be positively associated with childhood growth. Methods. We analysed data on 23,967 mother-infant pairs enrolled in the Collaborative Perinatal Project. In race-stratified regression models, the main outcomes were birthweight and z-score body-mass index (BMI) at ages 4 and 7. Results. Some placental measures were significantly associated with z-score BMI at age 7: in Blacks, placental weight (β = 0.0004/g; 95%CI: 0.0001, 0.0008), chorionic plate area (β = 0.0007; 95%CI: 0.0001, 0.0012) and largest diameter (β = 0.013; 95%CI: 0.004, 0.026); and in Whites placental weight (β = 0.0004/g; 95%CI: 0.0001, 0.0003) and largest diameter (Model 3: β = 0.020; 95%CI: 0.007, 0.032). Tested as group, placental measures significantly predicted z-score BMI at age 7 (all p values < 0.005). Conclusions. Placental structure independently predicts birthweight and childhood growth. Strategies to improve placental structure might favourably influence birthweight and childhood development.
AB - Objectives. We hypothesised that the gross placental measures would be positively associated with childhood growth. Methods. We analysed data on 23,967 mother-infant pairs enrolled in the Collaborative Perinatal Project. In race-stratified regression models, the main outcomes were birthweight and z-score body-mass index (BMI) at ages 4 and 7. Results. Some placental measures were significantly associated with z-score BMI at age 7: in Blacks, placental weight (β = 0.0004/g; 95%CI: 0.0001, 0.0008), chorionic plate area (β = 0.0007; 95%CI: 0.0001, 0.0012) and largest diameter (β = 0.013; 95%CI: 0.004, 0.026); and in Whites placental weight (β = 0.0004/g; 95%CI: 0.0001, 0.0003) and largest diameter (Model 3: β = 0.020; 95%CI: 0.007, 0.032). Tested as group, placental measures significantly predicted z-score BMI at age 7 (all p values < 0.005). Conclusions. Placental structure independently predicts birthweight and childhood growth. Strategies to improve placental structure might favourably influence birthweight and childhood development.
KW - BMI
KW - Birthweight
KW - Growth
KW - Placenta
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U2 - 10.1080/14767050802415728
DO - 10.1080/14767050802415728
M3 - Article
C2 - 19085212
AN - SCOPUS:61649098384
VL - 22
SP - 13
EP - 23
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
SN - 1476-7058
IS - 1
ER -