Green fluorescent protein-labeled mapping of neural stem cells migrating towards damaged areas in the adult central nervous system

Chang Zhou, Zhe Xing Wen, Zhi Ping Wang, Xing Guo, Dong Mei Shi, Huan Cong Zuo, Zuo Ping Xie

Research output: Contribution to journalArticlepeer-review

Abstract

Neural stem cells, which are clonogenic cells with multilineage differentiation properties from regions of the fetal brain, cortex and hippocampus, are currently considered as powerful candidates for cell replacement therapy in neurodegenerative disorders, such as Parkinson's disease. A key issue is whether stem cells can survive, migrate and differentiate following transplantation into the adult CNS. Here, enhanced green fluorescent protein plasmid electroporation-transfected neural stem cells from the fetal cortex were grafted into the striatum of a rat model of Parkinson's disease. We found most of the grafted cells could survive in the adult parkinsonian rat brain and migrated towards damaged areas, while they moved randomly in the normal brain. Several grafted cells differentiated into neurons.

Original languageEnglish (US)
Pages (from-to)943-945
Number of pages3
JournalCell biology international
Volume27
Issue number11
DOIs
StatePublished - Nov 2003

Keywords

  • Engraftment
  • Enhanced green fluorescent protein (EGFP)
  • Migrate
  • Neural stem cells (NSCs)

ASJC Scopus subject areas

  • Cell Biology

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