TY - JOUR
T1 - Greater Skeletal Muscle Oxidative Capacity Is Associated with Higher Resting Metabolic Rate
T2 - Results from the Baltimore Longitudinal Study of Aging
AU - Zampino, Marta
AU - Semba, Richard D.
AU - Adelnia, Fatemeh
AU - Spencer, Richard G.
AU - Fishbein, Kenneth W.
AU - Schrack, Jennifer A.
AU - Simonsick, Eleanor M.
AU - Ferrucci, Luigi
N1 - Publisher Copyright:
© 2020 Published by Oxford University Press on behalf of The Gerontological Society of America 2020.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Resting metabolic rate (RMR) tends to decline with aging. The age-trajectory of decline in RMR is similar to changes that occur in muscle mass, muscle strength, and fitness, but while the decline in these phenotypes has been related to changes of mitochondrial function and oxidative capacity, whether lower RMR is associated with poorer mitochondrial oxidative capacity is unknown. In 619 participants of the Baltimore Longitudinal Study of Aging, we analyzed the cross-sectional association between RMR (kcal/day), assessed by indirect calorimetry, and skeletal muscle maximal oxidative phosphorylation capacity, assessed as postexercise phosphocreatine recovery time constant (τ PCr), by phosphorous magnetic resonance spectroscopy. Linear regression models were used to evaluate the relationship between τ PCr and RMR, adjusting for potential confounders. Independent of age, sex, lean body mass, muscle density, and fat mass, higher RMR was significantly associated with shorter τ PCr, indicating greater mitochondrial oxidative capacity. Higher RMR is associated with a higher mitochondrial oxidative capacity in skeletal muscle. This association may reflect a relationship between better muscle quality and greater mitochondrial health.
AB - Resting metabolic rate (RMR) tends to decline with aging. The age-trajectory of decline in RMR is similar to changes that occur in muscle mass, muscle strength, and fitness, but while the decline in these phenotypes has been related to changes of mitochondrial function and oxidative capacity, whether lower RMR is associated with poorer mitochondrial oxidative capacity is unknown. In 619 participants of the Baltimore Longitudinal Study of Aging, we analyzed the cross-sectional association between RMR (kcal/day), assessed by indirect calorimetry, and skeletal muscle maximal oxidative phosphorylation capacity, assessed as postexercise phosphocreatine recovery time constant (τ PCr), by phosphorous magnetic resonance spectroscopy. Linear regression models were used to evaluate the relationship between τ PCr and RMR, adjusting for potential confounders. Independent of age, sex, lean body mass, muscle density, and fat mass, higher RMR was significantly associated with shorter τ PCr, indicating greater mitochondrial oxidative capacity. Higher RMR is associated with a higher mitochondrial oxidative capacity in skeletal muscle. This association may reflect a relationship between better muscle quality and greater mitochondrial health.
KW - Biology of aging
KW - Metabolism
KW - Mitochondria
KW - Muscles
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U2 - 10.1093/gerona/glaa071
DO - 10.1093/gerona/glaa071
M3 - Article
C2 - 32201887
AN - SCOPUS:85092386796
SN - 1079-5006
VL - 75
SP - 2262
EP - 2268
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 12
ER -