TY - JOUR
T1 - Greater Physical Activity Is Associated with Slower Visual Field Loss in Glaucoma
AU - Lee, Moon Jeong
AU - Wang, Jiangxia
AU - Friedman, David S.
AU - Boland, Michael
AU - De Moraes, Carlos G.
AU - Ramulu, Pradeep Y.
N1 - Funding Information:
Supported by the Dennis W. Jahnigen Memorial Award and National Institutes of Health Grant EY022976 . The sponsor or funding organization had no role in the design or conduct of this research.
Funding Information:
Supported by the Dennis W. Jahnigen Memorial Award and National Institutes of Health Grant EY022976. The sponsor or funding organization had no role in the design or conduct of this research. Financial Disclosure(s): The author(s) have made the following disclosure(s): M.V.B.: Personal fees ? Heidelberg Engineering; Grants ? Alcon. P.Y.R.: Grants ? National Eye Institute, National Institute of Aging/Jahnigen Foundation. Supported by the Dennis W. Jahnigen Memorial Award and National Institutes of Health Grant EY022976. The sponsor or funding organization had no role in the design or conduct of this research. Obtained funding: Boland, Ramulu
Publisher Copyright:
© 2018 American Academy of Ophthalmology
PY - 2019/7
Y1 - 2019/7
N2 - Purpose: To determine the association between physical activity levels and the rate of visual field (VF) loss in glaucoma. Design: Longitudinal, observational study. Participants: Older adults with suspect or manifest glaucoma. Methods: Participants wore accelerometers for 1 week to define average steps per day, minutes of moderate-to-vigorous activity, and minutes of nonsedentary activity. All available VF measurements before and after physical activity assessment were retrospectively analyzed to measure rates of VF loss. Main Outcome Measures: Pointwise changes in VF sensitivity associated with physical activity measures. Results: A total of 141 participants (mean age, 64.9±5.8 years) were enrolled. Eye mean deviation (MD) at the time of physical activity assessment was −6.6 decibels (dB), and average steps per day were 5613±3158. The unadjusted average rate of VF loss as measured by pointwise VF sensitivity was 0.36 dB/year (95% confidence interval, −0.37 to −0.35). In multivariable models, slower VF loss was observed for patients demonstrating more steps (+0.007 dB/year/1000 daily steps, P < 0.001), more moderate-to-vigorous activity (+0.003 dB/year/10 more minutes of moderate-to-vigorous activity per day, P < 0.001), and more nonsedentary activity (+0.007 dB/year/30 more minutes of nonsedentary time per day, P = 0.005). Factors associated with a faster rate of VF loss included older age, non-white race, glaucoma surgery, cataract surgery, and moderate baseline VF damage (–6 dB ≥ MD >–12 dB) as opposed to mild VF damage (MD >–6 dB). Similar associations between baseline accelerometer-measured physical activity and rates of VF loss were observed over other time periods (e.g., within 1, 3, and 5 years of activity assessment). Conclusions: Increased walking, greater time spent doing moderate-to-vigorous physical activity, and more time spent in nonsedentary activity were associated with slower rates of VF loss in a treated population of patients with glaucoma, with an additional 5000 daily steps or 2.6 hours of nonsedentary physical activity decreasing the average rate of VF loss by approximately 10%. Future prospective studies are needed to determine if physical activity can slow VF loss in glaucoma or if progressive VF loss results in activity restriction. If the former is confirmed, this would mark physical activity as a novel modifiable risk factor for preventing glaucoma damage.
AB - Purpose: To determine the association between physical activity levels and the rate of visual field (VF) loss in glaucoma. Design: Longitudinal, observational study. Participants: Older adults with suspect or manifest glaucoma. Methods: Participants wore accelerometers for 1 week to define average steps per day, minutes of moderate-to-vigorous activity, and minutes of nonsedentary activity. All available VF measurements before and after physical activity assessment were retrospectively analyzed to measure rates of VF loss. Main Outcome Measures: Pointwise changes in VF sensitivity associated with physical activity measures. Results: A total of 141 participants (mean age, 64.9±5.8 years) were enrolled. Eye mean deviation (MD) at the time of physical activity assessment was −6.6 decibels (dB), and average steps per day were 5613±3158. The unadjusted average rate of VF loss as measured by pointwise VF sensitivity was 0.36 dB/year (95% confidence interval, −0.37 to −0.35). In multivariable models, slower VF loss was observed for patients demonstrating more steps (+0.007 dB/year/1000 daily steps, P < 0.001), more moderate-to-vigorous activity (+0.003 dB/year/10 more minutes of moderate-to-vigorous activity per day, P < 0.001), and more nonsedentary activity (+0.007 dB/year/30 more minutes of nonsedentary time per day, P = 0.005). Factors associated with a faster rate of VF loss included older age, non-white race, glaucoma surgery, cataract surgery, and moderate baseline VF damage (–6 dB ≥ MD >–12 dB) as opposed to mild VF damage (MD >–6 dB). Similar associations between baseline accelerometer-measured physical activity and rates of VF loss were observed over other time periods (e.g., within 1, 3, and 5 years of activity assessment). Conclusions: Increased walking, greater time spent doing moderate-to-vigorous physical activity, and more time spent in nonsedentary activity were associated with slower rates of VF loss in a treated population of patients with glaucoma, with an additional 5000 daily steps or 2.6 hours of nonsedentary physical activity decreasing the average rate of VF loss by approximately 10%. Future prospective studies are needed to determine if physical activity can slow VF loss in glaucoma or if progressive VF loss results in activity restriction. If the former is confirmed, this would mark physical activity as a novel modifiable risk factor for preventing glaucoma damage.
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U2 - 10.1016/j.ophtha.2018.10.012
DO - 10.1016/j.ophtha.2018.10.012
M3 - Article
C2 - 30315900
AN - SCOPUS:85056237135
SN - 0161-6420
VL - 126
SP - 958
EP - 964
JO - Ophthalmology
JF - Ophthalmology
IS - 7
ER -