Gray matter alteration in patients with restless legs syndrome: A voxel-based morphometry study

Yongmin Chang; Hyuk Won Chang; Huijin Song; Jeonghun Ku; Christopher J. Earley; Richard P. Allen; Yong Won Cho

doi:10.1016/j.clinimag.2014.07.010

Gray matter alteration in patients with restless legs syndrome: A voxel-based morphometry study

Yongmin Chang, Hyuk Won Chang, Huijin Song, Jeonghun Ku, Christopher J. Earley, Richard P. Allen, Yong Won Cho

School of Medicine

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The purpose of this study was to demonstrate whether or not restless legs syndrome (RLS) is associated with any morphological change in gray matter. Forty-six RLS subjects and 46 controls were enrolled. We performed voxel-based morphometry analysis and compared the results of the two groups. The RLS subjects showed significant regional decreases of gray matter volume in the left hippocampal gyrus, both parietal lobes, medial frontal areas and cerebellum (uncorrected, P<. .001). We found that RLS patients showed structural alteration in the brain and alterations in certain parts of the brain in RLS patients are relevant to RLS.

Original language	English (US)
Pages (from-to)	20-25
Number of pages	6
Journal	Clinical Imaging
Volume	39
Issue number	1
DOIs	https://doi.org/10.1016/j.clinimag.2014.07.010
State	Published - Jan 1 2015

Keywords

Gray matter
MRI
Restless legs syndrome
Voxel-based morphometry

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1016/j.clinimag.2014.07.010

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title = "Gray matter alteration in patients with restless legs syndrome: A voxel-based morphometry study",

abstract = "The purpose of this study was to demonstrate whether or not restless legs syndrome (RLS) is associated with any morphological change in gray matter. Forty-six RLS subjects and 46 controls were enrolled. We performed voxel-based morphometry analysis and compared the results of the two groups. The RLS subjects showed significant regional decreases of gray matter volume in the left hippocampal gyrus, both parietal lobes, medial frontal areas and cerebellum (uncorrected, P<. .001). We found that RLS patients showed structural alteration in the brain and alterations in certain parts of the brain in RLS patients are relevant to RLS.",

keywords = "Gray matter, MRI, Restless legs syndrome, Voxel-based morphometry",

author = "Yongmin Chang and Chang, {Hyuk Won} and Huijin Song and Jeonghun Ku and Earley, {Christopher J.} and Allen, {Richard P.} and Cho, {Yong Won}",

note = "Funding Information: This work was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology ( 2011-0008025 ). Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

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AU - Song, Huijin

AU - Ku, Jeonghun

AU - Earley, Christopher J.

AU - Allen, Richard P.

AU - Cho, Yong Won

N1 - Funding Information: This work was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology ( 2011-0008025 ). Publisher Copyright: © 2015 Elsevier Inc.

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N2 - The purpose of this study was to demonstrate whether or not restless legs syndrome (RLS) is associated with any morphological change in gray matter. Forty-six RLS subjects and 46 controls were enrolled. We performed voxel-based morphometry analysis and compared the results of the two groups. The RLS subjects showed significant regional decreases of gray matter volume in the left hippocampal gyrus, both parietal lobes, medial frontal areas and cerebellum (uncorrected, P<. .001). We found that RLS patients showed structural alteration in the brain and alterations in certain parts of the brain in RLS patients are relevant to RLS.

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KW - Voxel-based morphometry

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Gray matter alteration in patients with restless legs syndrome: A voxel-based morphometry study

Abstract

Keywords

ASJC Scopus subject areas

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