Grass immunotherapy induces inhibition of allergen-specific human peripheral blood mononuclear cell proliferation

Sivasubramanian Baskar, Robert G. Hamilton, Philip S. Norman, Aftab A. Ansari

Research output: Contribution to journalArticle

Abstract

The peripheral blood mononuclear cells (PBMC) from humans allergic to grass pollens (GR + subjects) show strong in vitro proliferative responses to purified allergens from Lolium perenne pollen Lol p 1, and to a lesser extent to Lol p 2 and Lol p 3. By contrast, PBMC from grass allergic patients undergoing immunotherapy (GR + IT subjects) exhibit a very poor Lol p-specific proliferative response, similar to that observed in nongrass allergic subjects (GR− subjects). Unlike GR−subjects, both GR+ and GR + IT subjects have high levels of antigen-specific serum IgG and IgE antibodies to Lol p 1, Lol p 2 and Lol p 3. While GR+ subjects exhibit a significant correlation between antigen-specific serum antibody and PBMC responses, GR + IT sujects do not show a correlation between the two responses. The possible mechanisms by which immunotherapy may modulate allergen-specific T cell proliferative response are discussed.

Original languageEnglish (US)
Pages (from-to)184-190
Number of pages7
JournalInternational Archives of Allergy and Immunology
Volume112
Issue number2
DOIs
StatePublished - Jan 1 1997

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Keywords

  • Grass allergy
  • Immunotherapy
  • Lolium perenne
  • Peripheral blood mononuclear cells and antibody responses

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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