Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease

Donghoon Kim, Je Min Yoo, Heehong Hwang, Junghee Lee, Su Hyun Lee, Seung Pil Yun, Myung Jin Park, Min Jun Lee, Seulah Choi, Sang Ho Kwon, Saebom Lee, Seung Hwan Kwon, Sangjune Kim, Yong Joo Park, Misaki Kinoshita, Young Ho Lee, Seokmin Shin, Seung R. Paik, Sung Joong Lee, Seulki LeeByung Hee Hong, Hanseok Seok Ko

Research output: Contribution to journalArticle

Abstract

Graphene quantum dots inhibit the formation of alpha-synuclein fibrils and induce their dissociation in vitro, and display neuro-protective properties in in vivo models of Parkinson’s disease, with no appreciable long-term toxicity.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalNature Nanotechnology
DOIs
StateAccepted/In press - Jul 9 2018

Fingerprint

Parkinson disease
alpha-Synuclein
Graphite
toxicity
Graphene
Semiconductor quantum dots
Toxicity
graphene
quantum dots
dissociation

ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

Cite this

Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease. / Kim, Donghoon; Yoo, Je Min; Hwang, Heehong; Lee, Junghee; Lee, Su Hyun; Yun, Seung Pil; Park, Myung Jin; Lee, Min Jun; Choi, Seulah; Kwon, Sang Ho; Lee, Saebom; Kwon, Seung Hwan; Kim, Sangjune; Park, Yong Joo; Kinoshita, Misaki; Lee, Young Ho; Shin, Seokmin; Paik, Seung R.; Lee, Sung Joong; Lee, Seulki; Hong, Byung Hee; Ko, Hanseok Seok.

In: Nature Nanotechnology, 09.07.2018, p. 1-7.

Research output: Contribution to journalArticle

Kim, D, Yoo, JM, Hwang, H, Lee, J, Lee, SH, Yun, SP, Park, MJ, Lee, MJ, Choi, S, Kwon, SH, Lee, S, Kwon, SH, Kim, S, Park, YJ, Kinoshita, M, Lee, YH, Shin, S, Paik, SR, Lee, SJ, Lee, S, Hong, BH & Ko, HS 2018, 'Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease', Nature Nanotechnology, pp. 1-7. https://doi.org/10.1038/s41565-018-0179-y
Kim, Donghoon ; Yoo, Je Min ; Hwang, Heehong ; Lee, Junghee ; Lee, Su Hyun ; Yun, Seung Pil ; Park, Myung Jin ; Lee, Min Jun ; Choi, Seulah ; Kwon, Sang Ho ; Lee, Saebom ; Kwon, Seung Hwan ; Kim, Sangjune ; Park, Yong Joo ; Kinoshita, Misaki ; Lee, Young Ho ; Shin, Seokmin ; Paik, Seung R. ; Lee, Sung Joong ; Lee, Seulki ; Hong, Byung Hee ; Ko, Hanseok Seok. / Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease. In: Nature Nanotechnology. 2018 ; pp. 1-7.
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