Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease

Donghoon Kim; Je Min Yoo; Heehong Hwang; Junghee Lee; Su Hyun Lee; Seung Pil Yun; Myung Jin Park; Min Jun Lee; Seulah Choi; Sang Ho Kwon; Saebom Lee; Seung Hwan Kwon; Sangjune Kim; Yong Joo Park; Misaki Kinoshita; Young Ho Lee; Seokmin Shin; Seung R. Paik; Sung Joong Lee; Seulki Lee; Byung Hee Hong; Hanseok Seok Ko

doi:10.1038/s41565-018-0179-y

Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease

Donghoon Kim, Je Min Yoo, Heehong Hwang, Junghee Lee, Su Hyun Lee, Seung Pil Yun, Myung Jin Park, Min Jun Lee, Seulah Choi, Sang Ho Kwon, Saebom Lee, Seung Hwan Kwon, Sangjune Kim, Yong Joo Park, Misaki Kinoshita, Young Ho Lee, Seokmin Shin, Seung R. Paik, Sung Joong Lee, Seulki LeeByung Hee Hong, Hanseok Seok Ko

School of Medicine

Research output: Contribution to journal › Article

Abstract

Graphene quantum dots inhibit the formation of alpha-synuclein fibrils and induce their dissociation in vitro, and display neuro-protective properties in in vivo models of Parkinson’s disease, with no appreciable long-term toxicity.

Original language	English (US)
Pages (from-to)	1-7
Number of pages	7
Journal	Nature Nanotechnology
DOIs	https://doi.org/10.1038/s41565-018-0179-y
State	Accepted/In press - Jul 9 2018

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ASJC Scopus subject areas

Bioengineering
Atomic and Molecular Physics, and Optics
Biomedical Engineering
Materials Science(all)
Condensed Matter Physics
Electrical and Electronic Engineering

Cite this

Kim, D., Yoo, J. M., Hwang, H., Lee, J., Lee, S. H., Yun, S. P., Park, M. J., Lee, M. J., Choi, S., Kwon, S. H., Lee, S., Kwon, S. H., Kim, S., Park, Y. J., Kinoshita, M., Lee, Y. H., Shin, S., Paik, S. R., Lee, S. J., ... Ko, H. S. (Accepted/In press). Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease. Nature Nanotechnology, 1-7. https://doi.org/10.1038/s41565-018-0179-y

Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease. / Kim, Donghoon; Yoo, Je Min; Hwang, Heehong; Lee, Junghee; Lee, Su Hyun; Yun, Seung Pil; Park, Myung Jin; Lee, Min Jun; Choi, Seulah; Kwon, Sang Ho; Lee, Saebom; Kwon, Seung Hwan; Kim, Sangjune; Park, Yong Joo; Kinoshita, Misaki; Lee, Young Ho; Shin, Seokmin; Paik, Seung R.; Lee, Sung Joong; Lee, Seulki; Hong, Byung Hee; Ko, Hanseok Seok.

In: Nature Nanotechnology, 09.07.2018, p. 1-7.

Research output: Contribution to journal › Article

Kim, Donghoon ; Yoo, Je Min ; Hwang, Heehong ; Lee, Junghee ; Lee, Su Hyun ; Yun, Seung Pil ; Park, Myung Jin ; Lee, Min Jun ; Choi, Seulah ; Kwon, Sang Ho ; Lee, Saebom ; Kwon, Seung Hwan ; Kim, Sangjune ; Park, Yong Joo ; Kinoshita, Misaki ; Lee, Young Ho ; Shin, Seokmin ; Paik, Seung R. ; Lee, Sung Joong ; Lee, Seulki ; Hong, Byung Hee ; Ko, Hanseok Seok. / Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease. In: Nature Nanotechnology. 2018 ; pp. 1-7.

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10.1038/s41565-018-0179-y