Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease

Donghoon Kim; Je Min Yoo; Heehong Hwang; Junghee Lee; Su Hyun Lee; Seung Pil Yun; Myung Jin Park; Min Jun Lee; Seulah Choi; Sang Ho Kwon; Saebom Lee; Seung Hwan Kwon; Sangjune Kim; Yong Joo Park; Misaki Kinoshita; Young Ho Lee; Seokmin Shin; Seung R. Paik; Sung Joong Lee; Seulki Lee; Byung Hee Hong; Han Seok Ko

doi:10.1038/s41565-018-0179-y

Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease

Donghoon Kim, Je Min Yoo, Heehong Hwang, Junghee Lee, Su Hyun Lee, Seung Pil Yun, Myung Jin Park, Min Jun Lee, Seulah Choi, Sang Ho Kwon, Saebom Lee, Seung Hwan Kwon, Sangjune Kim, Yong Joo Park, Misaki Kinoshita, Young Ho Lee, Seokmin Shin, Seung R. Paik, Sung Joong Lee, Seulki LeeByung Hee Hong, Han Seok Ko

School of Medicine

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Abstract

Graphene quantum dots inhibit the formation of alpha-synuclein fibrils and induce their dissociation in vitro, and display neuro-protective properties in in vivo models of Parkinson’s disease, with no appreciable long-term toxicity.

Original language	English (US)
Pages (from-to)	812-818
Number of pages	7
Journal	Nature Nanotechnology
Volume	13
Issue number	9
DOIs	https://doi.org/10.1038/s41565-018-0179-y
State	Published - Sep 1 2018

ASJC Scopus subject areas

Bioengineering
Atomic and Molecular Physics, and Optics
Biomedical Engineering
General Materials Science
Condensed Matter Physics
Electrical and Electronic Engineering

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Kim, D., Yoo, J. M., Hwang, H., Lee, J., Lee, S. H., Yun, S. P., Park, M. J., Lee, M. J., Choi, S., Kwon, S. H., Lee, S., Kwon, S. H., Kim, S., Park, Y. J., Kinoshita, M., Lee, Y. H., Shin, S., Paik, S. R., Lee, S. J., ... Ko, H. S. (2018). Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease. Nature Nanotechnology, 13(9), 812-818. https://doi.org/10.1038/s41565-018-0179-y

Kim, D, Yoo, JM, Hwang, H, Lee, J, Lee, SH, Yun, SP, Park, MJ, Lee, MJ, Choi, S, Kwon, SH, Lee, S, Kwon, SH, Kim, S, Park, YJ, Kinoshita, M, Lee, YH, Shin, S, Paik, SR, Lee, SJ, Lee, S, Hong, BH & Ko, HS 2018, 'Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease', Nature Nanotechnology, vol. 13, no. 9, pp. 812-818. https://doi.org/10.1038/s41565-018-0179-y

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author = "Donghoon Kim and Yoo, {Je Min} and Heehong Hwang and Junghee Lee and Lee, {Su Hyun} and Yun, {Seung Pil} and Park, {Myung Jin} and Lee, {Min Jun} and Seulah Choi and Kwon, {Sang Ho} and Saebom Lee and Kwon, {Seung Hwan} and Sangjune Kim and Park, {Yong Joo} and Misaki Kinoshita and Lee, {Young Ho} and Seokmin Shin and Paik, {Seung R.} and Lee, {Sung Joong} and Seulki Lee and Hong, {Byung Hee} and Ko, {Han Seok}",

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AU - Yun, Seung Pil

AU - Park, Myung Jin

AU - Lee, Min Jun

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AU - Kwon, Sang Ho

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AU - Kwon, Seung Hwan

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AU - Paik, Seung R.

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Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease

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