Graph theoretical analysis of resting magnetoencephalographic 9 functional connectivity networks

Lindsay Rutter, Sreenivasan Rajamoni Nadar, Tom Holroyd, Frederick W. Carver, Jose Apud, Daniel R. Weinberger, Richard Coppola

Research output: Contribution to journalArticlepeer-review

Abstract

Complex networks have been observed to comprise small-world properties, believed to represent an optimal organization of local specialization and global integration of information processing at reduced wiring cost. Here, we applied magnitude squared coherence to resting magnetoencephalographic time series in reconstructed source space, acquired from controls and patients with schizophrenia, and generated frequency-dependent adjacency matrices modeling functional connectivity between virtual channels. After configuring undirected binary and weighted graphs, we found that all human networks demonstrated highly localized clustering and short characteristic path lengths. The most conservatively thresholded networks showed efficient wiring, with topographical distance between connected vertices amounting to one-third as observed in surrogate randomized topologies. Nodal degrees of the human networks conformed to a heavy-tailed exponentially truncated power-law, compatible with the existence of hubs, which included theta and alpha bilateral cerebellar tonsil, beta and gamma bilateral posterior cingulate, and bilateral thalamus across all frequencies. We conclude that all networks showed small-worldness, minimal physical connection distance, and skewed degree distributions characteristic of physically-embedded networks, and that these calculations derived from graph theoretical mathematics did not quantifiably distinguish between subject populations, independent of bandwidth. However, post-hoc measurements of edge computations at the scale of the individual vertex revealed trends of reduced gamma connectivity across the posterior medial parietal cortex in patients, an observation consistent with our prior resting activation study that found significant reduction of synthetic aperture magnetometry gamma power across similar regions. The basis of these small differences remains unclear.

Original languageEnglish (US)
JournalFrontiers in Computational Neuroscience
Issue numberJUN
DOIs
StatePublished - Jun 21 2013

Keywords

  • Clustering coefficient
  • Default network
  • Exponentially truncated power-law
  • Magnitude squared coherence
  • Path length
  • Schizophrenia
  • Small world
  • Synthetic aperture magnetometry

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Cellular and Molecular Neuroscience

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