Granzyme B-induced cell death

Research output: Contribution to journalArticle

Abstract

Granzyme B (GrB) is a serine protease that is released by cytotoxic lymphocytes to kill virus-infected and tumor cells. Recent advances in the understanding of GrB have stressed the importance of reassessing the mechanisms by which GrB accomplishes its death functions. These include the uptake and trafficking of GrB within target cells, pathways used to trigger cell death, and the mechanism(s) controlling its killing activity. In addition, the role that GrB plays in human pathologies is still to be defined. The purpose of this review is to discuss recent insights into the biology of GrB and to evaluate its functional significance in health and disease.

Original languageEnglish (US)
Pages (from-to)28-41
Number of pages14
JournalActa Haematologica
Volume111
Issue number1-2
DOIs
StatePublished - 2004

Fingerprint

Granzymes
Cell Death
Oncogenic Viruses
Serine Proteases
Lymphocytes
Pathology
Health

Keywords

  • Apoptosis
  • Caspase
  • CTL
  • Cytotoxicity
  • Granzyme B

ASJC Scopus subject areas

  • Hematology

Cite this

Granzyme B-induced cell death. / Andrade, Felipe A; Casciola Rosen, Livia A; Rosen, Antony.

In: Acta Haematologica, Vol. 111, No. 1-2, 2004, p. 28-41.

Research output: Contribution to journalArticle

@article{081ac31524ee4d63a59037c77841fdfe,
title = "Granzyme B-induced cell death",
abstract = "Granzyme B (GrB) is a serine protease that is released by cytotoxic lymphocytes to kill virus-infected and tumor cells. Recent advances in the understanding of GrB have stressed the importance of reassessing the mechanisms by which GrB accomplishes its death functions. These include the uptake and trafficking of GrB within target cells, pathways used to trigger cell death, and the mechanism(s) controlling its killing activity. In addition, the role that GrB plays in human pathologies is still to be defined. The purpose of this review is to discuss recent insights into the biology of GrB and to evaluate its functional significance in health and disease.",
keywords = "Apoptosis, Caspase, CTL, Cytotoxicity, Granzyme B",
author = "Andrade, {Felipe A} and {Casciola Rosen}, {Livia A} and Antony Rosen",
year = "2004",
doi = "10.1159/000074484",
language = "English (US)",
volume = "111",
pages = "28--41",
journal = "Acta Haematologica",
issn = "0001-5792",
publisher = "S. Karger AG",
number = "1-2",

}

TY - JOUR

T1 - Granzyme B-induced cell death

AU - Andrade, Felipe A

AU - Casciola Rosen, Livia A

AU - Rosen, Antony

PY - 2004

Y1 - 2004

N2 - Granzyme B (GrB) is a serine protease that is released by cytotoxic lymphocytes to kill virus-infected and tumor cells. Recent advances in the understanding of GrB have stressed the importance of reassessing the mechanisms by which GrB accomplishes its death functions. These include the uptake and trafficking of GrB within target cells, pathways used to trigger cell death, and the mechanism(s) controlling its killing activity. In addition, the role that GrB plays in human pathologies is still to be defined. The purpose of this review is to discuss recent insights into the biology of GrB and to evaluate its functional significance in health and disease.

AB - Granzyme B (GrB) is a serine protease that is released by cytotoxic lymphocytes to kill virus-infected and tumor cells. Recent advances in the understanding of GrB have stressed the importance of reassessing the mechanisms by which GrB accomplishes its death functions. These include the uptake and trafficking of GrB within target cells, pathways used to trigger cell death, and the mechanism(s) controlling its killing activity. In addition, the role that GrB plays in human pathologies is still to be defined. The purpose of this review is to discuss recent insights into the biology of GrB and to evaluate its functional significance in health and disease.

KW - Apoptosis

KW - Caspase

KW - CTL

KW - Cytotoxicity

KW - Granzyme B

UR - http://www.scopus.com/inward/record.url?scp=0344197675&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344197675&partnerID=8YFLogxK

U2 - 10.1159/000074484

DO - 10.1159/000074484

M3 - Article

VL - 111

SP - 28

EP - 41

JO - Acta Haematologica

JF - Acta Haematologica

SN - 0001-5792

IS - 1-2

ER -