Granulomatous encephalitis caused by Bipolaris hawaiiensis

S. J. Morton, K. Midthun, W. G. Merz

Research output: Contribution to journalArticle

Abstract

We describe a case of granulomatous encephalitis caused by Bipolaris (Drechslera) hawaiiensis in an immunocompetent patient. An 18-year-old man with a seven-month history of seizures and right leg weakness was found by computed tomographic scan to have a left frontoparietal enhancing lesion. Biopsy of the lesion revealed granulomatous inflammation and numerous septate hyphae. Culture of the biopsy specimen yielded a pure culture of B hawaiiensis in four days. Susceptibility studies revealed the organism to be sensitive to amphotericin B (minimal inhibitory concentration [MIC] equals 0.25 mg/L) and miconazole lactate (MIC equals 0.064 mg/L), but resistant to flucytosine (MIC > 100 mg/L). No synergy was demonstrated with amphotericin B and flucytosine in vitro. The patient was successfully treated with surgery and systemic and intrathecal amphotericin B therapy, and a negative culture was obtained from a repeated brain biopsy six weeks later.

Original languageEnglish (US)
Pages (from-to)1183-1185
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Volume110
Issue number12
StatePublished - 1986

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Amphotericin B
Encephalitis
Flucytosine
Biopsy
Miconazole
Hyphae
Lactic Acid
Leg
Seizures
Inflammation
Brain
Therapeutics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Morton, S. J., Midthun, K., & Merz, W. G. (1986). Granulomatous encephalitis caused by Bipolaris hawaiiensis. Archives of Pathology and Laboratory Medicine, 110(12), 1183-1185.

Granulomatous encephalitis caused by Bipolaris hawaiiensis. / Morton, S. J.; Midthun, K.; Merz, W. G.

In: Archives of Pathology and Laboratory Medicine, Vol. 110, No. 12, 1986, p. 1183-1185.

Research output: Contribution to journalArticle

Morton, SJ, Midthun, K & Merz, WG 1986, 'Granulomatous encephalitis caused by Bipolaris hawaiiensis', Archives of Pathology and Laboratory Medicine, vol. 110, no. 12, pp. 1183-1185.
Morton, S. J. ; Midthun, K. ; Merz, W. G. / Granulomatous encephalitis caused by Bipolaris hawaiiensis. In: Archives of Pathology and Laboratory Medicine. 1986 ; Vol. 110, No. 12. pp. 1183-1185.
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