Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease

Tiffany M. Powell; Jonathan D. Paul; Jonathan M. Hill; Michael Thompson; Moshe Benjamin; Maria Rodrigo; J. Philip McCoy; Elizabeth J. Read; Hanh M. Khuu; Susan F. Leitman; Toren Finkel; Richard O. Cannon

doi:10.1161/01.ATV.0000151690.43777.e4

Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease

Tiffany M. Powell, Jonathan D. Paul, Jonathan M. Hill, Michael Thompson, Moshe Benjamin, Maria Rodrigo, J. Philip McCoy, Elizabeth J. Read, Hanh M. Khuu, Susan F. Leitman, Toren Finkel, Richard O. Cannon

Research output: Contribution to journal › Article › peer-review

217 Scopus citations

Abstract

Objective - Endothelial progenitor cells (EPCs) that may repair vascular injury are reduced in patients with coronary artery disease (CAD). We reasoned that EPC number and function may be increased by granulocyte colony-stimulating factor (G-CSF) used to mobilize hematopoietic progenitor cells in healthy donors. Methods and Results - Sixteen CAD patients had reduced CD34 ⁺/CD133 ⁺ (0.0224±0.0063% versus 0.121±0.038% mononuclear cells [MNCs], P+/VEGFR-2 ⁺ cells, consistent with EPC phenotype (0.00033±0.00015% versus 0.0017±0.0006% MNCs, P+/CD133 ⁺ cells from 0.5±0.2/μL to 59.5±10.6/μL and CD133 ⁺/ VEGFR-2 ⁺ cells from 0.007±0.004/μL to 1.9±0.6/μL (both P+ cells that coexpressed the homing receptor CXCR4 (30.4±8.3/μL, P

Original language	English (US)
Pages (from-to)	296-301
Number of pages	6
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	25
Issue number	2
DOIs	https://doi.org/10.1161/01.ATV.0000151690.43777.e4
State	Published - Feb 2005
Externally published	Yes

Keywords

Angiogenesis
Atherosclerosis
Cell adhesion molecules
Cells
Coronary disease

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1161/01.ATV.0000151690.43777.e4

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Powell, T. M., Paul, J. D., Hill, J. M., Thompson, M., Benjamin, M., Rodrigo, M., McCoy, J. P., Read, E. J., Khuu, H. M., Leitman, S. F., Finkel, T., & Cannon, R. O. (2005). Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(2), 296-301. https://doi.org/10.1161/01.ATV.0000151690.43777.e4

Powell, TM, Paul, JD, Hill, JM, Thompson, M, Benjamin, M, Rodrigo, M, McCoy, JP, Read, EJ, Khuu, HM, Leitman, SF, Finkel, T & Cannon, RO 2005, 'Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 2, pp. 296-301. https://doi.org/10.1161/01.ATV.0000151690.43777.e4

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abstract = "Objective - Endothelial progenitor cells (EPCs) that may repair vascular injury are reduced in patients with coronary artery disease (CAD). We reasoned that EPC number and function may be increased by granulocyte colony-stimulating factor (G-CSF) used to mobilize hematopoietic progenitor cells in healthy donors. Methods and Results - Sixteen CAD patients had reduced CD34 +/CD133 + (0.0224±0.0063% versus 0.121±0.038% mononuclear cells [MNCs], P+/VEGFR-2 + cells, consistent with EPC phenotype (0.00033±0.00015% versus 0.0017±0.0006% MNCs, P+/CD133 + cells from 0.5±0.2/μL to 59.5±10.6/μL and CD133 +/ VEGFR-2 + cells from 0.007±0.004/μL to 1.9±0.6/μL (both P+ cells that coexpressed the homing receptor CXCR4 (30.4±8.3/μL, P",

keywords = "Angiogenesis, Atherosclerosis, Cell adhesion molecules, Cells, Coronary disease",

author = "Powell, {Tiffany M.} and Paul, {Jonathan D.} and Hill, {Jonathan M.} and Michael Thompson and Moshe Benjamin and Maria Rodrigo and McCoy, {J. Philip} and Read, {Elizabeth J.} and Khuu, {Hanh M.} and Leitman, {Susan F.} and Toren Finkel and Cannon, {Richard O.}",

year = "2005",

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doi = "10.1161/01.ATV.0000151690.43777.e4",

language = "English (US)",

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AU - Powell, Tiffany M.

AU - Paul, Jonathan D.

AU - Hill, Jonathan M.

AU - Thompson, Michael

AU - Benjamin, Moshe

AU - Rodrigo, Maria

AU - McCoy, J. Philip

AU - Read, Elizabeth J.

AU - Khuu, Hanh M.

AU - Leitman, Susan F.

AU - Finkel, Toren

AU - Cannon, Richard O.

PY - 2005/2

Y1 - 2005/2

N2 - Objective - Endothelial progenitor cells (EPCs) that may repair vascular injury are reduced in patients with coronary artery disease (CAD). We reasoned that EPC number and function may be increased by granulocyte colony-stimulating factor (G-CSF) used to mobilize hematopoietic progenitor cells in healthy donors. Methods and Results - Sixteen CAD patients had reduced CD34 +/CD133 + (0.0224±0.0063% versus 0.121±0.038% mononuclear cells [MNCs], P+/VEGFR-2 + cells, consistent with EPC phenotype (0.00033±0.00015% versus 0.0017±0.0006% MNCs, P+/CD133 + cells from 0.5±0.2/μL to 59.5±10.6/μL and CD133 +/ VEGFR-2 + cells from 0.007±0.004/μL to 1.9±0.6/μL (both P+ cells that coexpressed the homing receptor CXCR4 (30.4±8.3/μL, P

AB - Objective - Endothelial progenitor cells (EPCs) that may repair vascular injury are reduced in patients with coronary artery disease (CAD). We reasoned that EPC number and function may be increased by granulocyte colony-stimulating factor (G-CSF) used to mobilize hematopoietic progenitor cells in healthy donors. Methods and Results - Sixteen CAD patients had reduced CD34 +/CD133 + (0.0224±0.0063% versus 0.121±0.038% mononuclear cells [MNCs], P+/VEGFR-2 + cells, consistent with EPC phenotype (0.00033±0.00015% versus 0.0017±0.0006% MNCs, P+/CD133 + cells from 0.5±0.2/μL to 59.5±10.6/μL and CD133 +/ VEGFR-2 + cells from 0.007±0.004/μL to 1.9±0.6/μL (both P+ cells that coexpressed the homing receptor CXCR4 (30.4±8.3/μL, P

KW - Angiogenesis

KW - Atherosclerosis

KW - Cell adhesion molecules

KW - Cells

KW - Coronary disease

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Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease

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