Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease

Tiffany M. Powell, Jonathan D. Paul, Jonathan M. Hill, Michael Thompson, Moshe Benjamin, Maria Rodrigo, J. Philip McCoy, Elizabeth J. Read, Hanh M. Khuu, Susan F. Leitman, Toren Finkel, Richard O. Cannon

Research output: Contribution to journalArticle

Abstract

Objective - Endothelial progenitor cells (EPCs) that may repair vascular injury are reduced in patients with coronary artery disease (CAD). We reasoned that EPC number and function may be increased by granulocyte colony-stimulating factor (G-CSF) used to mobilize hematopoietic progenitor cells in healthy donors. Methods and Results - Sixteen CAD patients had reduced CD34 +/CD133 + (0.0224±0.0063% versus 0.121±0.038% mononuclear cells [MNCs], P+/VEGFR-2 + cells, consistent with EPC phenotype (0.00033±0.00015% versus 0.0017±0.0006% MNCs, P+/CD133 + cells from 0.5±0.2/μL to 59.5±10.6/μL and CD133 +/ VEGFR-2 + cells from 0.007±0.004/μL to 1.9±0.6/μL (both P+ cells that coexpressed the homing receptor CXCR4 (30.4±8.3/μL, P

Original languageEnglish (US)
Pages (from-to)296-301
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume25
Issue number2
DOIs
StatePublished - Feb 2005
Externally publishedYes

Keywords

  • Angiogenesis
  • Atherosclerosis
  • Cell adhesion molecules
  • Cells
  • Coronary disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Powell, T. M., Paul, J. D., Hill, J. M., Thompson, M., Benjamin, M., Rodrigo, M., McCoy, J. P., Read, E. J., Khuu, H. M., Leitman, S. F., Finkel, T., & Cannon, R. O. (2005). Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(2), 296-301. https://doi.org/10.1161/01.ATV.0000151690.43777.e4