Granular small bowel mucosa: A reflection of villous abnormality

Bronwyn Jones, Stanley R. Hamilton, Stephen E. Rubesin, Theodore M. Bayless, William J. Ravich, Thomas R. Hendrix

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Diffuse mucosal granularity was reported recently in small bowel Crohn's disease. The radiographic appearance corresponded on histopathologic examination to villous hypertrophy, fusion, or epithelial bridge formation. We have observed similar granularity in Crohn's disease but also in several other conditions, including radiation enteritis, pancreatic glucagonoma, protein-losing enteropathy, and small bowel ischemia. Histopathologic examination demonstrated various alterations in villous morphology, such as edema, hyperplasia, clubbing, or fusion. In Crohn's disease, this appearance was sometimes an indication of early inflammatory disease but was also seen following extensive small bowel resection, possibly due to villous enlargement resulting from intestinal adaptation. These findings suggest that granular mucosa in the small bowel is a nonspecific finding reflecting an alteration in villous structure.

Original languageEnglish (US)
Pages (from-to)219-225
Number of pages7
JournalGastrointestinal Radiology
Issue number1
StatePublished - Dec 1987


  • Intestine, radiography
  • Villous pattern, abnormalities

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology


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